Abstract | OBJECTIVE: MATERIALS AND METHODS: This retrospective study included 25 patients with exon 19 short inframe deletion (exon 19) and 21 patients with exon 21 L858R point (exon 21) EGFR mutations among 125 patients with EGFR mutant adenocarcinoma of the lung. The randomly formed control group consisted of 20 patients selected from 126 patients with EGFR mutation-negative (wild-type) adenocarcinomas. Five gray-level texture features (contrast, correlation, inverse difference moment, angular second moment, and entropy) were analyzed. RESULTS: Contrast differentiated both exon 19 (p = 0.00027) and exon 21 (p = 0.00001) mutants from the wild type. Wild-type adenocarcinomas had high scores for contrast (mean, 1598.547) compared with EGFR mutants (mean, 679.463). Correlation differentiated both exon 19 (p = 0.017) and exon 21 (p = 0.0015) mutants from wild-type adenocarcinomas. Inverse difference moment differentiated exon 19 mutants from exon 21 mutants (p = 0.019) and both exon 19 (p = 0.044) and exon 21 (p = 0.00001) mutants from wild-type adenocarcinomas. Angular second moment and entropy were not associated with statistically significant differences between mutation statuses. CONCLUSION: Contrast, correlation, and inverse difference moment texture features correlate with EGFR mutation status in adenocarcinoma of the lung. Further investigation with larger prospective studies is needed to validate the role of CT gray-level texture analysis as a quantitative imaging biomarker.
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Authors | Efe Ozkan, Anna West, Jeffrey A Dedelow, Benjamin F Chu, Weiqiang Zhao, Vedat O Yildiz, Gregory A Otterson, Konstantin Shilo, Subha Ghosh, Mark King, Richard D White, Barbaros S Erdal |
Journal | AJR. American journal of roentgenology
(AJR Am J Roentgenol)
Vol. 205
Issue 5
Pg. 1016-25
(Nov 2015)
ISSN: 1546-3141 [Electronic] United States |
PMID | 26496549
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- EGFR protein, human
- ErbB Receptors
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Topics |
- Adenocarcinoma
(diagnostic imaging, genetics, pathology)
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- ErbB Receptors
(genetics)
- Exons
- Female
- Humans
- Lung Neoplasms
(diagnostic imaging, genetics, pathology)
- Male
- Middle Aged
- Mutation
- Neoplasm Staging
- Radiographic Image Interpretation, Computer-Assisted
- Retrospective Studies
- Tomography, X-Ray Computed
(methods)
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