Abstract |
The St George's Respiratory Questionnaire (SGRQ) is a validated, commonly used questionnaire for measuring quality of life in patients with chronic obstructive pulmonary disease ( COPD). The current established minimal important difference (MID) for SGRQ scores in an average COPD population is -4 units. However, for patients with severe COPD, the MID has not been thoroughly validated. We re-determined the SGRQ MID for this patient group.115 severe COPD patients (forced expiratory volume in 1 s (FEV1) 26±9% of predicted, SGRQ score 62±11 units; mean±sd,) who participated in seven different bronchoscopic lung volume reduction clinical trials were included in the analysis. Anchor- and distribution-based methods were used to define the MID for SGRQ scores. FEV1, 6-min walk distance and residual volume were used as anchors.Combining both anchor- and distribution-based methods, we identified a SGRQ MID of -8.3 units at 1 month and -7.1 units at 6 months.This study proposes an alternative SGRQ MID for patients with severe COPD of -8.3 units at 1 month and -7.1 units at 6 months follow-up after intervention. Our new MID estimates could be applied for both interpreting SGRQ outcomes as well as sample size determination in future clinical trials investigating interventions in severe COPD patients.
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Authors | Jorrit B A Welling, Jorine E Hartman, Nick H T Ten Hacken, Karin Klooster, Dirk-Jan Slebos |
Journal | The European respiratory journal
(Eur Respir J)
Vol. 46
Issue 6
Pg. 1598-604
(Dec 2015)
ISSN: 1399-3003 [Electronic] England |
PMID | 26493797
(Publication Type: Journal Article)
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Copyright | Copyright ©ERS 2015. |
Topics |
- Aged
- Exercise Test
- Exercise Tolerance
(physiology)
- Female
- Forced Expiratory Volume
- Humans
- Male
- Middle Aged
- Outcome Assessment, Health Care
- Pneumonectomy
- Pulmonary Disease, Chronic Obstructive
(physiopathology, surgery)
- Quality of Life
- Residual Volume
- Retrospective Studies
- Severity of Illness Index
- Surveys and Questionnaires
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