Chronic pain: the burden of disease and treatment innovations.

Abstract

Musculoskeletal conditions are the most frequent cause of chronic pain and affect around 1 in 5 adults in Europe. When chronic pain occurs, it becomes disease itself, with substantial clinical, social and economic impact. Efficacy and tolerability problems are encountered with all therapeutic strategies available to treat musculoskeletal pain. This often limits effective analgesia and patients' long term compliance, with the result that chronic pain is persistently underestimated and undertreated. Tapentadol is a novel, centrally acting analgesic that has been recently commercialized for the treatment of chronic pain. This new molecule, by combining two distinct mechanisms of action, μ-opioid receptor agonism (MOR) and noradrenaline reuptake inhibition (NRI), introduces a new pharmacological class called MOR-NRI. Several studies demonstrated promising results in the management of both nociceptive and neuropathic pain and good tolerability profile, particularly concerning side effects, compared to traditional opioids. This novel analgesic represents a possible therapeutic option also in the rheumatologic field, particularly in the treatment of osteoarthritis and low back pain.

• Authors: S Monti, R Caporali
• Journal: Reumatismo (Reumatismo) Vol. 67 Issue 2 Pg. 35-44 (Oct 23 2015) ISSN: 0048-7449 [Print] Italy
• PMID: 26492961 (Publication Type: Journal Article, Review)

Chemical References

• Narcotics
• Norepinephrine Plasma Membrane Transport Proteins
• Phenols
• Receptors, Opioid, mu
• Tapentadol

Topics

• Adult
• Chronic Pain (drug therapy, epidemiology)
• Clinical Trials as Topic
• Cost of Illness
• Europe (epidemiology)
• Humans
• Multicenter Studies as Topic
• Musculoskeletal Pain (drug therapy, epidemiology)
• Narcotics (therapeutic use)
• Neuralgia (drug therapy)
• Nociception (drug effects)
• Norepinephrine Plasma Membrane Transport Proteins (antagonists & inhibitors)
• Osteoarthritis (drug therapy, epidemiology)
• Phenols (adverse effects, pharmacology, therapeutic use)
• Receptors, Opioid, mu (agonists)
• Tapentadol
• Therapies, Investigational
• United States (epidemiology)