Abstract | BACKGROUND: There were several reports suggesting α- adrenoceptor antagonists are effective to treat neuropathic pain. The aims of this study were as follows: (1) to introduce drug delivery system for dorsal root ganglion (DRG) neurons; (2) to elucidate the effects of α- adrenoceptor antagonists in acute, subacute or chronic phase and (3) to determine which subtype of adrenoceptor was mainly involved. METHOD: We used 130 male Sprague-Dawley rats. After root constriction, rats received three local injections of α- adrenoceptor antagonists around DRG. We administered the non-selective α- adrenoceptor antagonist phentolamine for 3 consecutive days from day 0, 4 or 11 after the surgery, and the α1-adrenoceptor antagonist prazosin, the α1-adrenoceptor antagonist silodosin, the more preferred α1-adrenoceptor than prazosin and the α2-adrenoceptor antagonist yohimbine for 3 consecutive days from day 0 after the surgery. RESULTS: CONCLUSIONS: This study showed α- adrenoceptor antagonists could suppress pain behaviour via α2-adrenoceptor in acute phase and temporary attenuate pain behaviour in chronic phase. These findings presented potentials sympathetic nerve blockade contributed to treat neuropathic pain.
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Authors | I Ogon, T Takebayashi, T Miyakawa, T Iwase, K Tanimoto, Y Terashima, S Jimbo, T Kobayashi, N Tohse, T Yamashita |
Journal | European journal of pain (London, England)
(Eur J Pain)
Vol. 20
Issue 5
Pg. 790-9
(May 2016)
ISSN: 1532-2149 [Electronic] England |
PMID | 26492290
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 European Pain Federation - EFIC® |
Chemical References |
- Adrenergic alpha-1 Receptor Antagonists
- Adrenergic alpha-2 Receptor Antagonists
- Adrenergic alpha-Antagonists
- Indoles
- Yohimbine
- silodosin
- Prazosin
- Phentolamine
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Topics |
- Adrenergic alpha-1 Receptor Antagonists
(pharmacology)
- Adrenergic alpha-2 Receptor Antagonists
(pharmacology)
- Adrenergic alpha-Antagonists
(pharmacology)
- Animals
- Behavior, Animal
(drug effects)
- Disease Models, Animal
- Ganglia, Spinal
(injuries)
- Indoles
(pharmacology)
- Male
- Neuralgia
- Pain Measurement
- Phentolamine
(pharmacology)
- Prazosin
(pharmacology)
- Radiculopathy
- Rats
- Rats, Sprague-Dawley
- Yohimbine
(pharmacology)
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