[Identification of Circulating Tumor Cell（CTC）in Breast Cancer Patients Using a Newly Established CTC Detecting System].

Abstract

We developed a new circulating tumor cell (CTC) chip in order to identify CTCs in the peripheral blood of cancer patients. In this study, we aimed to identify CTCs in the blood of breast cancer patients by using this CTC detecting system. In addition, we used this system to evaluate the response to anticancer agents. We were able to identify CTCs in 5 of 6 patients. In addition, the system showed that the number of CTCs had decreased after chemotherapy. Thus, the CTC detecting system was useful in the identification of CTCs in the breast cancer patients and in the early prediction of response to anticancer agents.

• Authors: Takuya Nagata, Takashi Ohnaga, Xiao Long Lu, Toru Watanabe, Katsuhisa Hirano, Tomoyuki Okumura, Kazuhiro Tsukada
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 42 Issue 10 Pg. 1240-2 (Oct 2015) ISSN: 0385-0684 [Print] Japan
• PMID: 26489559 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antinematodal Agents

Topics

• Antinematodal Agents (therapeutic use)
• Breast Neoplasms (drug therapy, pathology)
• Early Detection of Cancer
• Humans
• Lab-On-A-Chip Devices
• Microchip Analytical Procedures (methods)
• Neoplastic Cells, Circulating
• Treatment Outcome