[New Combination Therapy to Improve the Functional Preservation Rate of the Larynx in Laryngeal, Oropharyngeal, and Hypopharyngeal Cancers].

Abstract

A new combination therapy has been developed to achieve high overall survival and functional laryngeal preservation rates in head and neck cancers, which require laryngectomy. In order to treat the primary site without resection, superselective intra-arterial infusions with DCF anterogradely and 60 mg/m2 of DOC and 60 mg/m2 of CDDP via the femoral artery on day 1 were administered, followed by continuous intravenous instillation of 750 mg/m2/day of 5-FU for 5 days from day 2. The 5- year survival rate was 70.4% in laryngeal cancer, 72.8% in oropharyngeal cancer, and 68.5% in hypopharyngeal cancer. The 5-year functional laryngeal preservation rate was 71.0% in laryngeal cancer, 63.4% in oropharyngeal cancer, and 65.2% in hypopharyngeal cancer. In addition to regional lymph node control, a thorough neck dissection was performed. Good overall survival and functional laryngeal preservation rates were achieved.

• Authors: Tohru Furusaka
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 42 Issue 10 Pg. 1141-7 (Oct 2015) ISSN: 0385-0684 [Print] Japan
• PMID: 26489542 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Squamous Cell (physiopathology, therapy)
• Chemoradiotherapy
• Female
• Head and Neck Neoplasms (physiopathology, therapy)
• Humans
• Hypopharyngeal Neoplasms (pathology, physiopathology, therapy)
• Laryngeal Neoplasms (pathology, physiopathology, therapy)
• Lymphatic Metastasis
• Male
• Middle Aged
• Minimally Invasive Surgical Procedures
• Oropharyngeal Neoplasms (pathology, physiopathology, therapy)
• Squamous Cell Carcinoma of Head and Neck
• Treatment Outcome