Voriconazole-associated phototoxic dermatoses and skin cancer.

Abstract

Voriconazole's antifungal spectrum, oral bioavailability, and proven efficacy in treatment of invasive mycoses have led to its widespread off-label use for antifungal prophylaxis. There is an increasing recognition that long-term voriconazole use is associated with accelerated sun-induced skin changes that include acute phototoxicity reactions, photoaging, actinic keratosis and esp. among immunocompromised patients, skin cancers. The mechanisms underlying these dermatologic adverse events are not clearly understood. Population-risks of long-term voriconazole use need to be prospectively investigated. This review aims to provide an in-depth assessment of published literature and highlight salient findings from retrospective studies and case series. A broad practical guideline for assessment and management of these patients is provided.

• Authors: Rakesh K Goyal
• Journal: Expert review of anti-infective therapy (Expert Rev Anti Infect Ther) Vol. 13 Issue 12 Pg. 1537-46 ( 2015) ISSN: 1744-8336 [Electronic] England
• PMID: 26488688 (Publication Type: Journal Article, Review)

Chemical References

• Antifungal Agents
• Voriconazole

Topics

• Animals
• Antifungal Agents (adverse effects)
• Dermatitis, Phototoxic (diagnosis, epidemiology)
• Humans
• Skin Neoplasms (chemically induced, diagnosis, epidemiology)
• Voriconazole (adverse effects)