Near-IR mediated intracellular uncaging of NO from cell targeted hollow gold nanoparticles.

Abstract

We demonstrate modulation of nitric oxide release in solution and in human prostate cancer cells from a thiol functionalized cupferron (TCF) absorbed on hollow gold nanoshells (HGNs) using near-infrared (NIR) light. NO release from the TCF-HGN conjugates occurs through localized surface heating due to NIR excitation of the surface plasmon. Specific HGN targeting is achieved through cell surface directed peptides, and excitation with tissue penetrating NIR light provides unprecedented spatio-temporal control of NO delivery to biological targets.

• Authors: Elizabeth S Levy, Demosthenes P Morales, John V Garcia, Norbert O Reich, Peter C Ford
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 51 Issue 100 Pg. 17692-5 (Dec 28 2015) ISSN: 1364-548X [Electronic] England
• PMID: 26486468 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Nitric Oxide Donors
• Peptides
• Neuropilin-1
• Nitric Oxide
• Polyethylene Glycols
• Gold
• Nitric Oxide Synthase
• NG-Nitroarginine Methyl Ester

Topics

• Drug Delivery Systems
• Endocytosis (physiology)
• Gold (chemistry)
• HeLa Cells
• Humans
• Light
• NG-Nitroarginine Methyl Ester (pharmacology)
• Nanoshells (chemistry)
• Neuropilin-1 (physiology)
• Nitric Oxide (metabolism)
• Nitric Oxide Donors (chemistry, metabolism)
• Nitric Oxide Synthase (antagonists & inhibitors)
• Peptides (chemistry)
• Photolysis
• Polyethylene Glycols (chemistry)