TNFRs and Control of Chronic LCMV Infection: Implications for Therapy.

Abstract

The control of persistent viral infections requires the immune system to limit the spread of the virus while avoiding immunopathology. Recent studies have revealed that members of the tumor necrosis factor receptor (TNFR) superfamily play unique and pivotal roles in control of chronic lymphocytic choriomeningitis virus (LCMV) infection and in some settings can tip the balance between immune control and immune pathology. We review these findings and discuss how our understanding of the role of TNFRs in the immune response to chronic LCMV infection may shed light on what happens during HIV infection in humans. We discuss preclinical models of TNF/TNFR family-targeted immunotherapy of chronic LCMV infection and evaluate which TNFRs present the most promising targets for immune intervention.

• Authors: Derek L Clouthier, Tania H Watts
• Journal: Trends in immunology (Trends Immunol) Vol. 36 Issue 11 Pg. 697-708 (Nov 2015) ISSN: 1471-4981 [Electronic] England
• PMID: 26481667 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Receptors, Tumor Necrosis Factor

Topics

• Animals
• Arenaviridae Infections (immunology, therapy, virology)
• Chronic Disease
• Humans
• Immunotherapy
• Lymphocytic choriomeningitis virus (immunology, isolation & purification)
• Receptors, Tumor Necrosis Factor (immunology)