HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The usefulness of KL-6 and SP-D for the diagnosis and management of chronic hypersensitivity pneumonitis.

AbstractBACKGROUND:
It is believed that Krebs von den Lungen-6 (KL-6) and surfactant protein D (SP-D) are useful biomarkers for the diagnosis of various types of interstitial lung diseases, including hypersensitivity pneumonitis (HP). The clinical features of chronic HP are similar to those of idiopathic interstitial pneumonias, especially idiopathic pulmonary fibrosis (IPF).
OBJECTIVE:
We sought to clarify the usefulness of serum KL-6 and SP-D for the diagnosis and management of chronic HP.
METHODS:
We examined serum KL-6 and SP-D levels and retrospectively evaluated the clinical parameters of acute HP (n = 35), chronic HP (n = 57), IPF (n = 54), collagen vascular disease-associated interstitial pneumonia (CVD-IP) (n = 67), and sarcoidosis (n = 47). We analyzed the relations between the two biomarkers and clinical data in chronic HP.
RESULTS:
Serum KL-6 and SP-D levels in acute HP (2710 U/ml and 338 ng/ml, median) and chronic HP (1500 U/ml and 264 ng/ml, median) were significantly higher than in IPF, CVD-IP, and sarcoidosis. The area under the curve (AUC) values for serum KL-6 and SP-D between chronic HP and IPF were 0.771 and 0.729, respectively. Serum KL-6 levels in chronic HP were significantly higher during episodes of acute exacerbation than 1 month before acute exacerbation. The serum KL-6 levels had correlations with serum SP-D and the percentage of lymphocytes in bronchoalveolar lavage fluid.
CONCLUSIONS:
Serum KL-6 and SP-D levels are useful for the diagnosis and management of chronic HP.
AuthorsTsukasa Okamoto, Mayumi Fujii, Haruhiko Furusawa, Kimitake Tsuchiya, Yasunari Miyazaki, Naohiko Inase
JournalRespiratory medicine (Respir Med) Vol. 109 Issue 12 Pg. 1576-81 (Dec 2015) ISSN: 1532-3064 [Electronic] England
PMID26481343 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier Ltd. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents
  • Biomarkers
  • MUC1 protein, human
  • Mucin-1
  • Pulmonary Surfactant-Associated Protein D
  • Prednisolone
Topics
  • Adult
  • Aged
  • Alveolitis, Extrinsic Allergic (diagnosis, drug therapy)
  • Anti-Inflammatory Agents (therapeutic use)
  • Biomarkers (metabolism)
  • Chronic Disease
  • Diagnosis, Differential
  • Female
  • Humans
  • Idiopathic Pulmonary Fibrosis (diagnosis)
  • Male
  • Middle Aged
  • Mucin-1 (metabolism)
  • Prednisolone (therapeutic use)
  • Pulmonary Surfactant-Associated Protein D (metabolism)
  • Retrospective Studies
  • Sarcoidosis, Pulmonary
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: