Abstract | BACKGROUND: OBJECTIVE: We sought to clarify the usefulness of serum KL-6 and SP-D for the diagnosis and management of chronic HP. METHODS: RESULTS: Serum KL-6 and SP-D levels in acute HP (2710 U/ml and 338 ng/ml, median) and chronic HP (1500 U/ml and 264 ng/ml, median) were significantly higher than in IPF, CVD-IP, and sarcoidosis. The area under the curve (AUC) values for serum KL-6 and SP-D between chronic HP and IPF were 0.771 and 0.729, respectively. Serum KL-6 levels in chronic HP were significantly higher during episodes of acute exacerbation than 1 month before acute exacerbation. The serum KL-6 levels had correlations with serum SP-D and the percentage of lymphocytes in bronchoalveolar lavage fluid. CONCLUSIONS: Serum KL-6 and SP-D levels are useful for the diagnosis and management of chronic HP.
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Authors | Tsukasa Okamoto, Mayumi Fujii, Haruhiko Furusawa, Kimitake Tsuchiya, Yasunari Miyazaki, Naohiko Inase |
Journal | Respiratory medicine
(Respir Med)
Vol. 109
Issue 12
Pg. 1576-81
(Dec 2015)
ISSN: 1532-3064 [Electronic] England |
PMID | 26481343
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Ltd. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents
- Biomarkers
- MUC1 protein, human
- Mucin-1
- Pulmonary Surfactant-Associated Protein D
- Prednisolone
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Topics |
- Adult
- Aged
- Alveolitis, Extrinsic Allergic
(diagnosis, drug therapy)
- Anti-Inflammatory Agents
(therapeutic use)
- Biomarkers
(metabolism)
- Chronic Disease
- Diagnosis, Differential
- Female
- Humans
- Idiopathic Pulmonary Fibrosis
(diagnosis)
- Male
- Middle Aged
- Mucin-1
(metabolism)
- Prednisolone
(therapeutic use)
- Pulmonary Surfactant-Associated Protein D
(metabolism)
- Retrospective Studies
- Sarcoidosis, Pulmonary
- Treatment Outcome
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