Caerulomycin A inhibits Th2 cell activity: a possible role in the management of asthma.

Abstract

We have recently demonstrated that Caerulomycin A induces regulatory T cells differentiation by suppressing Th1 cells activity. The role of regulatory T cells is well established in suppressing the function of Th2 cells. Th2 cells are known to inflict the induction of the activation of asthma. Consequently, in the present study, we monitored the influence of Caerulomycin A in inhibiting the activity of Th2 cells and its impact in recuperating asthma symptoms. Interestingly, we observed that Caerulomycin A significantly suppressed the differentiation of Th2 cells, as evidenced by downregulation in the GATA-3 expression. Further, decline in the levels of IL-4, IL-5 and IL-13 cytokines and IgE was noted in the animals suffering from asthma. Furthermore, we noticed substantial suppression in the inflammatory response and number of eosinophils in the lungs. In essence, this study signifies an important therapeutic role of Caerulomycin A in asthma.

• Authors: Weshely Kujur, Rama Krishna Gurram, Nazia Haleem, Sudeep K Maurya, Javed N Agrewala
• Journal: Scientific reports (Sci Rep) Vol. 5 Pg. 15396 (Oct 20 2015) ISSN: 2045-2322 [Electronic] England
• PMID: 26481184 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytokines
• GATA3 Transcription Factor
• Pyridines
• caerulomycin A
• Immunoglobulin E

Topics

• Animals
• Asthma (drug therapy, genetics, immunology, metabolism, pathology)
• Cell Differentiation (drug effects, immunology)
• Cytokines (metabolism)
• Disease Models, Animal
• Disease Progression
• Eosinophils (immunology, pathology)
• Female
• GATA3 Transcription Factor (genetics, metabolism)
• Gene Expression Regulation (drug effects)
• Immunoglobulin E (blood, immunology)
• Leukocyte Count
• Lung (immunology, metabolism, pathology)
• Lymphocyte Activation (drug effects, immunology)
• Mice
• Pyridines (pharmacology)
• Severity of Illness Index
• Th2 Cells (cytology, drug effects, immunology, metabolism)