Polymorphisms in Protamine 1 and Protamine 2 predict the risk of male infertility: a meta-analysis.

Abstract

Several studies have investigated the association between polymorphisms in protamine 1 and 2 genes and male infertility risk, with inconsistent results to date. This meta-analysis based on the 13 published case-control studies, including 7350 cases and 6167 controls, was performed to further establish the potential association between the 6 common single nucleotide polymorphisms (rs35576928, rs737008, rs35262993, rs2301365, rs1646022, rs2070923) in protamines 1 and 2 and male infertility. The -190C > A (rs2301365) polymorphism was identified as a risk factor for male infertility under all models. Interestingly, rs1646022 and rs737008 polymorphisms exerted protective effects against male sterility in Asian and population-based under some models. No associations between the remaining SNPs and male sterility were observed.

• Authors: Weijun Jiang, Hui Sun, Jing Zhang, Qing Zhou, Qiuyue Wu, Tianfu Li, Cui Zhang, Weiwei Li, Mingchao Zhang, Xinyi Xia
• Journal: Scientific reports (Sci Rep) Vol. 5 Pg. 15300 (Oct 16 2015) ISSN: 2045-2322 [Electronic] England
• PMID: 26472740 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• PRM1 protein, human
• Protamines
• protamine 2

Topics

• Alleles
• Asian People (genetics)
• Databases, Factual
• Humans
• Infertility, Male (genetics, pathology)
• Male
• Odds Ratio
• Polymorphism, Single Nucleotide
• Protamines (genetics)
• Risk Factors