Abstract | INTRODUCTION: SUBJECTS AND METHODS: We conducted a prospective sequential cross-over, randomized controlled study in patients undergoing surgical removal of at least two impacted mandibular third molars (teeth numbers 38 and 48) (numbers 17 and 32 in the Universal Tooth Numbering System), in two separate sessions, to determine the effect of BP in comparison with bicarbonate (BC) oral rinse (one spoonful in 200 ml of water), both used three times daily. Each subject utilized both products in a randomized sequential manner after each tooth extraction. Primary outcomes of the study were post-procedure pain and inflammation. Secondary outcomes were analgesic pill rescue use ( metamizole 1 cap every 8 hours if needed) and an assessor-blinded evaluation of cicatrization with a semi-quantitative scale (good, satisfactory and insufficient). Post-procedure pain was assessed 6 hours after tooth extraction and for seven consecutive days by means of a 10 cm visual analogue scale (VAS) (from 0: no pain to 10: extreme pain). The extent of inflammation was evaluated through metric measurements of facial perimeter using standardized anatomical reference points. RESULTS: A total of 47 patients (22 men and 25 women; mean age 34 years) were enrolled with a total of 94 molars extracted. Nineteen subjects applied BC as the first sequential treatment and 28 BP as the first. Before surgery no mean differences in the two treatments in inflammation measurements were observed. After surgery mean VAS pain score was similar between the two treatments in the first 6 hours (VAS score = 6.5). A marked progressive reduction in pain intensity with the use of BP was observed throughout the treatment period in comparison with BC (7 day mean scores 3.7 vs. 5.3; p = 0.0001). BP was superior to BC in reducing inflammation with -50% of the inflammation-related measurement (6 mm vs. 12 mm; p = 0.0001). Analgesic pill consumption was lower with BP in comparison with BC (13 pills vs. 24; p < 0.05). Cicatrization was scored 'good' in a higher percentage of subjects during BP use (64%) in comparison with the BC group (13%) (p = 0.0001). No serious side effects were reported with either treatment regimen. CONCLUSION:
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Authors | Jose Lopez-Lopez, Jose Lope-Lopez, Enric Jan-Pallí, Beatriz Gonzá lez-Navarro, Beatriz González-Navarro, Enric Jané-Salas, Albert Estrugo-Devesa, Massimo Milani |
Journal | Current medical research and opinion
(Curr Med Res Opin)
Vol. 31
Issue 12
Pg. 2179-83
(Dec 2015)
ISSN: 1473-4877 [Electronic] England |
PMID | 26471464
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics
- Bicarbonates
- Pantothenic Acid
- dexpanthenol
- Allantoin
- Chitosan
- Chlorhexidine
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Topics |
- Adult
- Allantoin
(administration & dosage)
- Analgesics
(therapeutic use)
- Bicarbonates
(administration & dosage)
- Chitosan
(administration & dosage)
- Chlorhexidine
(administration & dosage)
- Cicatrix
(prevention & control)
- Cross-Over Studies
- Female
- Humans
- Inflammation
(drug therapy)
- Male
- Middle Aged
- Pain Measurement
- Pain, Postoperative
(drug therapy)
- Pantothenic Acid
(administration & dosage, analogs & derivatives)
- Prospective Studies
- Tooth Extraction
(methods)
- Young Adult
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