HIV reverse transcriptase gene mutations in anti-retroviral treatment naïve rural people living with HIV/AIDS.

Abstract

This study is designed to find out the mutational variations of reverse transcriptase (RT) gene of HIV, after the traditional drug usage among anti-retroviral therapy naïve rural people living with HIV/AIDS. HIV Reactive patients, who were exposed for indigenous medicines such as Siddha, Ayurveda etc., for a minimum period of 6 months were taken for this study. Among 40 patients, two samples (5.55%) demonstrated high-level mutational resistance variations for nucleoside RT inhibitor (NRTI) and non-NRTI. The predominant polymorphisms detected were K122E (91.7%), V60I (91.7%), V35T (89%), Q207E (89%), D177E (89%), T200A (86.1%), S48T (83.33%), K173A (80.6%).

• Authors: K Mohanakrishnan, A Kasthuri, S K Amsavathani, G Sumathi
• Journal: Indian journal of medical microbiology (Indian J Med Microbiol) 2015 Oct-Dec Vol. 33 Issue 4 Pg. 565-7 ISSN: 1998-3646 [Electronic] United States
• PMID: 26470965 (Publication Type: Journal Article)

Chemical References

• HIV Reverse Transcriptase

Topics

• Amino Acid Substitution
• Female
• Gene Frequency
• HIV (enzymology, isolation & purification)
• HIV Infections (virology)
• HIV Reverse Transcriptase (genetics)
• Humans
• Male
• Mutation, Missense
• Rural Population