Knowledge about
cancer cell behavior on heterogeneous nanostructures is relevant for developing a distinct
biomaterial that can actuate
cancer cells. In this manuscript, we have demonstrated a harmonized approach of forming multi Ti-
oxide phases in a nanostructure (
MTOP nanostructure) for its unique
cancer cell controlling behavior.Conventionally, single phases of TiO2 are used for targeted
therapy and as
drug carrier systems.In this research, we have shown a
biomaterial that can control HeLa cells diligently using a combination of TiO, Ti3O and TiO2 phases when compared to fibroblast (NIH3T3) cells.
MTOP-nanostructures are generated by varying the ionization energy in the vapor plume of the ultrashort pulse
laser; this interaction with the material allows accurate tuning and composition of phases within the nanostructure. In addition, the lattice spacing of
MTOP-nanostructures was analyzed as shown by HR-TEM investigations. An FESEM investigation of
MTOP-nanostructures revealed a greater reduction of HeLa cells relative to fibroblast cells. Altered cell adhesion was followed by modulation of HeLa cell architecture with a significant reduction of actin stress fibers.The intricate combination of
MTOP-nanostructures renders a
biomaterial that can precisely alter HeLa cell but not fibroblast cell behavior, filling a void in the research for a
biomaterial to modulate
cancer cell behavior.