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Dramatic transient improvement of metastatic BRAF(V600E)-mutated Langerhans cell sarcoma under treatment with dabrafenib.

AuthorsSamia Mourah, Gwenaël Lorillon, Véronique Meignin, Laetitia Vercellino, Constance de Margerie-Mellon, Cécile Pages, Lauriane Goldwirt, Alexandre How-Kit, Jorg Tost, Céleste Lebbe, Abdellatif Tazi
JournalBlood (Blood) Vol. 126 Issue 24 Pg. 2649-52 (Dec 10 2015) ISSN: 1528-0020 [Electronic] United States
PMID26468227 (Publication Type: Case Reports, Letter)
Chemical References
  • Antineoplastic Agents
  • Azetidines
  • Imidazoles
  • Indoles
  • Neoplasm Proteins
  • Oximes
  • Piperidines
  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins
  • Sulfonamides
  • Vemurafenib
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf
  • MAP Kinase Kinase Kinases
  • MAP3K8 protein, human
  • cobimetinib
  • dabrafenib
  • Prednisone
Topics
  • Antineoplastic Agents (therapeutic use)
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
  • Azetidines (administration & dosage)
  • Cyclophosphamide (administration & dosage)
  • Doxorubicin (administration & dosage)
  • Drug Resistance, Neoplasm
  • Drug Substitution
  • Humans
  • Imidazoles (therapeutic use)
  • Indoles (administration & dosage)
  • Langerhans Cell Sarcoma (diagnostic imaging, drug therapy, genetics, pathology)
  • Lymph Nodes (diagnostic imaging, pathology)
  • MAP Kinase Kinase Kinases (antagonists & inhibitors, biosynthesis, genetics)
  • Male
  • Middle Aged
  • Molecular Targeted Therapy
  • Multimodal Imaging
  • Mutation, Missense
  • Neoplasm Proteins (antagonists & inhibitors, genetics)
  • Oximes (therapeutic use)
  • Piperidines (administration & dosage)
  • Point Mutation
  • Positron-Emission Tomography
  • Prednisone (administration & dosage)
  • Protein Kinase Inhibitors (therapeutic use)
  • Proto-Oncogene Proteins (antagonists & inhibitors, biosynthesis, genetics)
  • Proto-Oncogene Proteins B-raf (antagonists & inhibitors, genetics)
  • Recurrence
  • Sulfonamides (administration & dosage)
  • Tomography, X-Ray Computed
  • Vemurafenib
  • Vincristine (administration & dosage)

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