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Serum adsorption, cellular internalization and consequent impact of cuprous oxide nanoparticles on uveal melanoma cells: implications for cancer therapy.

AbstractAIM:
To investigate the biological fate of cuprous oxide nanoparticles (Cu2O-NPs) and to evaluate their potential in uveal melanoma therapy.
MATERIALS & METHODS:
The protein corona, cellular uptake mechanism and localization of Cu2O-NPs were investigated. Furthermore, the effect of Cu2O-NPs on uveal melanoma cell proliferation, migration and invasion, and possible mechanisms were studied in detail.
RESULTS:
Cu2O-NPs are able to adsorb serum proteins in cell culture medium, which are then internalized by uveal melanoma cells mainly through lipid raft-mediated endocytosis. Furthermore, Cu2O-NPs selectively inhibit cancer cell growth and impair the ability of uveal melanoma cell migration, invasion and the cytoskeleton assembly. The mechanism may be that Cu2O-NPs located in and damage mitochondria, autophagolysosomes and lysosomes, leading to elevated reactive oxygen species level and over-stimulated apoptosis and autophagy.
CONCLUSION:
The data provide detailed information of Cu2O-NPs for further application and indicate that Cu2O-NPs could be a potential agent for uveal melanoma therapy.
AuthorsHongyuan Song, Qingqiang Xu, Yongzhe Zhu, Shiying Zhu, Hailin Tang, Yan Wang, Hao Ren, Ping Zhao, Zhongtian Qi, Shihong Zhao
JournalNanomedicine (London, England) (Nanomedicine (Lond)) Vol. 10 Issue 24 Pg. 3547-62 ( 2015) ISSN: 1748-6963 [Electronic] England
PMID26467678 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Copper
  • cuprous oxide
Topics
  • Cell Line, Tumor
  • Cell Movement (drug effects)
  • Cell Proliferation (drug effects)
  • Copper (administration & dosage, chemistry)
  • Humans
  • Melanoma (drug therapy, pathology)
  • Nanoparticles (administration & dosage, chemistry)
  • Neoplasm Invasiveness (pathology)
  • Uveal Neoplasms (drug therapy, pathology)

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