Repair of surgical wounds in rats using a 10% unripe Musa sapientum peel gel.

Abstract

PURPOSE:

To investigate the efficacy of a 10% gel of unripe banana (Musa sapientum) peel in treating surgical wounds in rats.

METHODS:

A longitudinal, prospective, randomized triple-blind study was conducted with 60 Wistar rats (Rattus norvegicus albinus) weighing approximately 400g. The animals were randomly divided into: control group (treated with gel containing no active ingredient) and study group (treated with 10% gel of unripe banana peel). The gel was applied every three days to a 4x4-cm surgical wound created on the back of each animal (day 0) in both groups. Tissue samples were collected for histological analysis on days 14, 21 and 28.

RESULTS:

On day 14, more extensive vascular proliferation (p=0.023), presence of mononuclear cells (p=0.000), fibroblast proliferation (p=0.012), re-epithelialization (p=0.000), and decreased presence of polymorphonuclear cells (p=0.010) were observed in the study group than in controls. No significant between-group difference in the presence of polymorphonuclear cells was found on day 21. Fibroblast proliferation was significantly greater (p=0.006) in the study group than in the control group on day 28.

CONCLUSION:

The 10% gel of unripe banana peel showed anti-inflammatory activity and stimulated wound healing in rat skin when compared with a gel containing no active ingredient.

• Authors: Dênia Amélia Novato Castelli Von Atzingen, Adriana Rodrigues dos Anjos Mendonça, Marcos Mesquita Filho, Vinícius Alves Alvarenga, Vinícius Almeida Assis, Afonso Esteves Penazzo, Julio Henrique Muzetti, Thaisa Sousa Rezende
• Journal: Acta cirurgica brasileira (Acta Cir Bras) Vol. 30 Issue 9 Pg. 586-92 (Sep 2015) ISSN: 1678-2674 [Electronic] Brazil
• PMID: 26465101 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Gels
• Plant Extracts

Topics

• Animals
• Anti-Inflammatory Agents (administration & dosage)
• Cell Proliferation (drug effects)
• Dose-Response Relationship, Drug
• Fibroblasts (drug effects)
• Gels (administration & dosage)
• Male
• Musa (chemistry)
• Phytotherapy (methods)
• Plant Extracts (administration & dosage)
• Prospective Studies
• Random Allocation
• Rats, Wistar
• Skin (drug effects)
• Time Factors
• Treatment Outcome
• Wound Healing (drug effects)
• Wounds and Injuries (drug therapy)