Abstract | BACKGROUND: METHODS/DESIGN: This is a multicenter, open-label, randomized, parallel-controlled clinical trial. One thousand eight hundred elderly patients (age range 60-90 years) who are scheduled to undergo major thoracic or abdominal surgery are randomized to receive either general anesthesia plus postoperative intravenous analgesia or combined epidural- general anesthesia plus postoperative epidural analgesia. The primary outcome is the 7-day incidence of postoperative delirium. Secondary outcomes include the duration of postoperative delirium, the intensity of pain during the first three days after surgery, the 30-day incidences of postoperative non- delirium complications, the length of stay in hospital after surgery and 30-day all-cause mortality. DISCUSSION: Results of the present study will provide information to guide clinical practice in choosing appropriate anesthesia- analgesia method for elderly patients undergoing major thoracic and abdominal surgery. TRIAL REGISTRATION: The study is registered on ClinicalTrials.gov NCT01661907 and Chinese Clinical Trial Registry ChiCTR-TRC-12002371 .
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Authors | Ya-Wei Li, Hui-Juan Li, Huai-Jin Li, Yi Feng, Yao Yu, Xiang-Yang Guo, Yan Li, Bin-Jiang Zhao, Xiao-Yun Hu, Ming-Zhang Zuo, Hong-Ye Zhang, Mei-Rong Wang, Ping Ji, Xiao-Yan Yan, Yang-Feng Wu, Dong-Xin Wang |
Journal | BMC anesthesiology
(BMC Anesthesiol)
Vol. 15
Pg. 144
(Oct 13 2015)
ISSN: 1471-2253 [Electronic] England |
PMID | 26459347
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Topics |
- Aged
- Aged, 80 and over
- Analgesia, Epidural
(methods)
- Anesthesia, Epidural
(methods)
- Anesthesia, General
(methods)
- Anesthesia, Intravenous
(methods)
- Delirium
(diagnosis, epidemiology, prevention & control)
- Female
- Follow-Up Studies
- Humans
- Incidence
- Male
- Middle Aged
- Pain, Postoperative
(diagnosis, prevention & control)
- Postoperative Complications
(diagnosis, epidemiology, prevention & control)
- Thoracic Surgical Procedures
(adverse effects)
- Treatment Outcome
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