Abstract | PURPOSE OF REVIEW: Adoptive T-cell therapy has become one of the most exciting fields of cancer therapy in the past few years. In this article, we describe a method which combines adoptive T-cell therapy with antibody therapy by arming T cells from cord blood, normal patients, and cancer patients with bispecific antibodies capable of binding to tumor-associated antigens on one side of the bispecific antibody construct and T cells on another side of the construct. This approach redirects T cells against tumor cells in a non-MHC-restricted manner. RECENT FINDINGS: SUMMARY:
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Authors | Divaya Bhutani, Lawrence G Lum |
Journal | Current opinion in hematology
(Curr Opin Hematol)
Vol. 22
Issue 6
Pg. 476-83
(Nov 2015)
ISSN: 1531-7048 [Electronic] United States |
PMID | 26457960
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
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Topics |
- Antibodies, Bispecific
(immunology, therapeutic use)
- Humans
- Immunotherapy, Adoptive
- Lymphocyte Activation
(immunology)
- Neoplasms
(immunology, pathology, therapy)
- T-Lymphocytes
(cytology, immunology)
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