Abstract | INTRODUCTION: METHODS: Participants were randomized to high-dose (4000 IU/d) versus low-dose (400 IU/d) oral vitamin D3 for 6 months. 24 hr ambulatory blood pressure (BP), carotid-femoral pulse wave velocity, and pulse wave analyses were obtained at baseline and after 6 months of vitamin D supplementation. RESULTS: There were no changes in resting BP or pulse wave velocity over 6 mo regardless of vitamin D dose (all p > 0.202). High-dose vitamin D decreased augmentation index and pressure by 12.3 ± 5.3% (p = 0.047) and 4.0 ± 1.5 mmHg (p = 0.02), respectively. However, these decreases in arterial stiffness were not associated with increases in serum 25-hydroxyvitamin D over 6 mo (p = 0.425). CONCLUSION: High-dose vitamin D supplementation appears to lower surrogate measures of arterial stiffness but not indices of central pulse wave velocity. Clinical Trial Registration. This trial is registered with www.clinicaltrials.gov (Unique Identifier: NCT01240512).
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Authors | Amanda Zaleski, Gregory Panza, Heather Swales, Pankaj Arora, Christopher Newton-Cheh, Thomas Wang, Paul D Thompson, Beth Taylor |
Journal | Disease markers
(Dis Markers)
Vol. 2015
Pg. 918968
( 2015)
ISSN: 1875-8630 [Electronic] United States |
PMID | 26451070
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Blood Pressure
- Female
- Humans
- Male
- Middle Aged
- Prehypertension
(drug therapy, etiology)
- Pulse Wave Analysis
- Vascular Stiffness
- Vitamin D
(administration & dosage, therapeutic use)
- Vitamin D Deficiency
(complications, drug therapy)
- Vitamins
(administration & dosage, therapeutic use)
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