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High-Dose versus Low-Dose Vitamin D Supplementation and Arterial Stiffness among Individuals with Prehypertension and Vitamin D Deficiency.

AbstractINTRODUCTION:
Vitamin D deficiency is associated with the onset and progression of hypertension and cardiovascular disease (CVD). However, mechanisms underlying vitamin D deficiency-mediated increased risk of CVD remain unknown. We sought to examine the differential effect of high-dose versus low-dose vitamin D supplementation on markers of arterial stiffness among ~40 vitamin D deficient adults with prehypertension.
METHODS:
Participants were randomized to high-dose (4000 IU/d) versus low-dose (400 IU/d) oral vitamin D3 for 6 months. 24 hr ambulatory blood pressure (BP), carotid-femoral pulse wave velocity, and pulse wave analyses were obtained at baseline and after 6 months of vitamin D supplementation.
RESULTS:
There were no changes in resting BP or pulse wave velocity over 6 mo regardless of vitamin D dose (all p > 0.202). High-dose vitamin D decreased augmentation index and pressure by 12.3 ± 5.3% (p = 0.047) and 4.0 ± 1.5 mmHg (p = 0.02), respectively. However, these decreases in arterial stiffness were not associated with increases in serum 25-hydroxyvitamin D over 6 mo (p = 0.425).
CONCLUSION:
High-dose vitamin D supplementation appears to lower surrogate measures of arterial stiffness but not indices of central pulse wave velocity. Clinical Trial Registration. This trial is registered with www.clinicaltrials.gov (Unique Identifier: NCT01240512).
AuthorsAmanda Zaleski, Gregory Panza, Heather Swales, Pankaj Arora, Christopher Newton-Cheh, Thomas Wang, Paul D Thompson, Beth Taylor
JournalDisease markers (Dis Markers) Vol. 2015 Pg. 918968 ( 2015) ISSN: 1875-8630 [Electronic] United States
PMID26451070 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Vitamins
  • Vitamin D
Topics
  • Adult
  • Blood Pressure
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prehypertension (drug therapy, etiology)
  • Pulse Wave Analysis
  • Vascular Stiffness
  • Vitamin D (administration & dosage, therapeutic use)
  • Vitamin D Deficiency (complications, drug therapy)
  • Vitamins (administration & dosage, therapeutic use)

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