Economic and Survival Implications of Use of Electric Power Morcellation for Hysterectomy for Presumed Benign Gynecologic Disease.

Electric power morcellation during laparoscopic hysterectomy allows some women to undergo minimally invasive surgery but may disrupt underlying occult malignancies and increase the risk of tumor dissemination.
We developed a state transition Markov cohort simulation model of the risks and benefits of hysterectomy (abdominal, laparoscopic, and laparoscopic with electric power morcellation) for women with presumed benign gynecologic disease. The model considered perioperative morbidity, mortality, risk of cancer and dissemination, and outcomes in women with an underlying malignancy. We explored the effectiveness from a societal perspective stratified by age (<40, 40-49, 50-59, and ≥60 years).
Under all scenarios, modeled laparoscopic hysterectomy without morcellation was the most beneficial strategy. Laparoscopic hysterectomy with morcellation was associated with 80.83 more intraoperative complications, 199.64 fewer perioperative complications, and 241.80 fewer readmissions than abdominal hysterectomy per 10 000 women. Per 10 000 women younger than age 40 years, laparoscopic hysterectomy with morcellation was associated with 1.57 more cases of disseminated cancer and 0.97 fewer deaths than abdominal hysterectomy. The excess cases of disseminated cancer per 10 000 women with morcellation compared with abdominal hysterectomy increased with age to 47.54 per 10 000 in women age 60 years and older. Compared with abdominal hysterectomy, this resulted in 0.30 (age 40-49 years), 5.07 (age 50-59 years), and 18.14 (age 60 years and older) excess deaths per 10 000 women in the respective age groups.
Laparoscopic hysterectomy without morcellation is the most beneficial approach of the three methods of hysterectomy studied. In older women, the risks of electric power morcellation may outweigh the benefits of minimally invasive hysterectomy.
AuthorsJason D Wright, Rosa R Cui, Anqi Wang, Ling Chen, Ana I Tergas, William M Burke, Cande V Ananth, June Y Hou, Alfred I Neugut, Sarah M Temkin, Y Claire Wang, Dawn L Hershman
JournalJournal of the National Cancer Institute (J Natl Cancer Inst) Vol. 107 Issue 11 (Nov 2015) ISSN: 1460-2105 [Electronic] United States
PMID26449386 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Copyright© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
  • Adult
  • Aged
  • Cost-Benefit Analysis
  • Electricity
  • Female
  • Genital Diseases, Female (economics, mortality, surgery)
  • Humans
  • Hysterectomy (economics, methods)
  • Laparoscopy
  • Leiomyoma (economics, mortality, surgery)
  • Middle Aged
  • Survival Analysis
  • United States (epidemiology)
  • Uterine Neoplasms (economics, mortality, surgery)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: