Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts.

Abstract

Transforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is necessary for the lipid rafts' structure and function. Euphol is a euphane-type triterpene alcohol that is structurally similar to cholesterol and has a wide range of pharmacological properties, including anti-inflammatory and anti-cancer effects. In the present study, euphol suppressed TGF-β signaling by inducing TGF-β receptor movement into lipid-raft microdomains and degrading TGF-β receptors.

• Authors: Chun-Lin Chen, Ying-Pin Chen, Ming-Wei Lin, Yaw-Bin Huang, Fang-Rong Chang, Tsai-Hui Duh, Deng-Chyang Wu, Wei-Chiang Wu, Yu-Chen Kao, Pei-Hua Yang
• Journal: PloS one (PLoS One) Vol. 10 Issue 10 Pg. e0140249 ( 2015) ISSN: 1932-6203 [Electronic] United States
• PMID: 26448474 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fibronectins
• Plant Extracts
• Receptors, Transforming Growth Factor beta
• Transforming Growth Factor beta
• Lanosterol
• euphol

Topics

• Cell Line, Tumor
• Euphorbia (chemistry)
• Fibronectins (genetics, metabolism)
• Gene Expression
• Humans
• Lanosterol (analogs & derivatives, pharmacology)
• Membrane Microdomains (metabolism)
• Phosphorylation
• Plant Extracts (pharmacology)
• Protein Processing, Post-Translational
• Protein Transport
• Proteolysis
• Receptors, Transforming Growth Factor beta (metabolism)
• Stomach Neoplasms
• Transcriptional Activation
• Transforming Growth Factor beta (physiology)