Mannitol metabolism during pathogenic fungal-host interactions under stressed conditions.

Abstract

Numerous plants and fungi produce mannitol, which may serve as an osmolyte or metabolic store; furthermore, mannitol also acts as a powerful quencher of reactive oxygen species (ROS). Some phytopathogenic fungi use mannitol to stifle ROS-mediated plant resistance. Mannitol is essential in pathogenesis to balance cell reinforcements produced by both plants and animals. Mannitol likewise serves as a source of reducing power, managing coenzymes, and controlling cytoplasmic pH by going about as a sink or hotspot for protons. The metabolic pathways for mannitol biosynthesis and catabolism have been characterized in filamentous fungi by direct diminishment of fructose-6-phosphate into mannitol-1-phosphate including a mannitol-1-phosphate phosphatase catalyst. In plants mannitol is integrated from mannose-6-phosphate to mannitol-1-phosphate, which then dephosphorylates to mannitol. The enzyme mannitol dehydrogenase plays a key role in host-pathogen interactions and must be co-localized with pathogen-secreted mannitol to resist the infection.

• Authors: Mukesh Meena, Vishal Prasad, Andleeb Zehra, Vijai K Gupta, Ram S Upadhyay
• Journal: Frontiers in microbiology (Front Microbiol) Vol. 6 Pg. 1019 ( 2015) ISSN: 1664-302X [Print] Switzerland
• PMID: 26441941 (Publication Type: Journal Article, Review)