Cefcapene Pivoxil Hydrochloride Is a Potentially New Treatment for Palmoplantar Pustulosis with Pustulotic Arthro-Osteitis.

Abstract

Pustulosis palmaris et plantaris or palmoplantar pustulosis (PPP) is a refractory pustular eruption of the palms and soles with unknown etiology. In addition to skin lesions, PPP patients may present with severe joint pain and pustulotic arthro-osteitis (PAO), especially of the sternoclavicular joint. PAO is sometimes regarded as a variant of synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. Hence, macrolide and tetracycline antibiotics are used for the treatment of PPP with PAO. We report 3 cases of PPP with PAO that did not improve upon administration of macrolide antibiotics with NSAIDs. After administration of cefcapene pivoxil hydrochloride (CFPN-PI), a third-generation cephalosporin, the swelling and sternoclavicular joint pain were promptly reduced and dramatically improved in all 3 cases. We review the conventional antibiotic treatments used currently and propose CFPN-PI as a potentially new therapy for PPP or PPP + PAO.

• Authors: Masamoto Murakami, Kana Masuda, Ryo Utsunomiya, Fumiko Oda, Chika Namba, Koji Sayama
• Journal: Dermatology (Basel, Switzerland) (Dermatology) Vol. 231 Issue 4 Pg. 304-11 ( 2015) ISSN: 1421-9832 [Electronic] Switzerland
• PMID: 26440444 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2015 S. Karger AG, Basel.

Chemical References

• Anti-Bacterial Agents
• Cephalosporins
• cefcapene pivoxil hydrochloride

Topics

• Acquired Hyperostosis Syndrome (drug therapy)
• Adult
• Anti-Bacterial Agents (therapeutic use)
• Cephalosporins (therapeutic use)
• Female
• Foot Dermatoses (drug therapy)
• Hand Dermatoses (drug therapy)
• Humans
• Male
• Middle Aged