Abstract | BACKGROUND:
Prostate cancer is a major concern of public health. Microvascular density (MVD) is one of the prognostic markers for various solid cancers. Matrix metalloproteinase 11 (MMP11) plays an important role in angiogenesis and changes in its expression level are known to be associated with tumor progression and clinical outcome. AIM: To investigate the relationship between MVD and MMP11 expression in prostatic adenocarcinoma tissues. MATERIALS AND METHODS: The expression levels of MMP11 and MVD were analyzed immunohistochemically for 50 specimens of prostatic adenocarcinoma. RESULTS: MMP11 was mainly expressed in stromal cells but rarely seen in epithelial cells. Mean MVD was 36/mm2, and it was correlated significantly only with bone metastases. MVD was also significantly correlated with MMP11 expression (r=0.29, p=0.044). CONCLUSIONS:
|
Authors | Nongnuch Kanharat, Panya Tuamsuk |
Journal | Asian Pacific journal of cancer prevention : APJCP
(Asian Pac J Cancer Prev)
Vol. 16
Issue 15
Pg. 6639-43
( 2015)
ISSN: 2476-762X [Electronic] Thailand |
PMID | 26434888
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Matrix Metalloproteinase 11
|
Topics |
- Adenocarcinoma
(blood supply, chemistry, secondary)
- Aged
- Aged, 80 and over
- Bone Neoplasms
(secondary)
- Epithelial Cells
(chemistry)
- Humans
- Male
- Matrix Metalloproteinase 11
(analysis)
- Microvessels
(pathology)
- Middle Aged
- Prostatic Neoplasms
(blood supply, chemistry, pathology)
- Stromal Cells
(chemistry)
- Thailand
|