Increased food intake with oxyntomodulin analogues.

Abstract

Oxyntomodulin analogues offer a novel treatment for obesity. However during analogue screening in a rat model increased food intake was consistently observed. To further investigate this finding, a series of representative analogues (OXM14 and OXM15) and their Glu-3 equivalents (OXM14E3 and OXM15E3) were administered to rats for 7 days and food intake and bodyweight measurements taken. To investigate the role of glucagon receptor activation glutamate (Glu/E) was substituted at amino acid position 3. GLP-1 and glucagon receptor efficacy of the oxyntomodulin analogues and their Glu-3 counterparts were measured at the rat receptors in vitro. Doses of 25 nmol/kg of OXM14 and OXM15 increased food intake by up to 20%. Bodyweight was not significantly increased. Food intake was not increased with the Glu-3 peptides, indicating that a glucagon receptor mechanism may be responsible for the increase in food intake.

• Authors: Samantha L Price, James S Minnion, Stephen R Bloom
• Journal: Peptides (Peptides) Vol. 73 Pg. 95-100 (Nov 2015) ISSN: 1873-5169 [Electronic] United States
• PMID: 26431789 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Chemical References

• Oxyntomodulin

Topics

• Animals
• Body Weight (drug effects)
• CHO Cells
• Cricetinae
• Cricetulus
• Eating (drug effects)
• Male
• Oxyntomodulin (chemistry, pharmacology)
• Rats
• Rats, Wistar