The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia.

Abstract

Acute myeloid leukemia (AML) is a heterogeneous disease whose prognosis is mainly related to the biological risk conferred by cytogenetics and molecular profiling. In elderly patients (⩾60 years) with normal karyotype AML miR-3151 have been identified as a prognostic factor. However, miR-3151 prognostic value has not been examined in younger AML patients. In the present work, we have studied miR-3151 alone and in combination with BAALC, its host gene, in a cohort of 181 younger intermediate-risk AML (IR-AML) patients. Patients with higher expression of miR-3151 had shorter overall survival (P=0.0025), shorter leukemia-free survival (P=0.026) and higher cumulative incidence of relapse (P=0.082). Moreover, in the multivariate analysis miR-3151 emerged as independent prognostic marker in both the overall series and within the unfavorable molecular prognostic category. Interestingly, the combined determination of both miR-3151 and BAALC improved this prognostic stratification, with patients with low levels of both parameters showing a better outcome compared with those patients harboring increased levels of one or both markers (P=0.003). In addition, we studied the microRNA expression profile associated with miR-3151 identifying a six-microRNA signature. In conclusion, the analysis of miR-3151 and BAALC expression may well contribute to an improved prognostic stratification of younger patients with IR-AML.

• Authors: M Díaz-Beyá, S Brunet, J Nomdedéu, A Cordeiro, M Tormo, L Escoda, J M Ribera, M Arnan, I Heras, D Gallardo, J Bargay, M P Queipo de Llano, O Salamero, J M Martí, A Sampol, C Pedro, M Hoyos, M Pratcorona, J J Castellano, M Nomdedeu, R M Risueño, J Sierra, M Monzó, A Navarro, J Esteve
• Journal: Blood cancer journal (Blood Cancer J) Vol. 5 Pg. e352 (Oct 02 2015) ISSN: 2044-5385 [Electronic] United States
• PMID: 26430723 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• BAALC protein, human
• Biomarkers, Tumor
• MIRN3151 microRNA, human
• MicroRNAs
• Neoplasm Proteins

Topics

• Adolescent
• Adult
• Aged
• Biomarkers, Tumor (genetics)
• Cytogenetic Analysis
• Disease-Free Survival
• Female
• Humans
• Kaplan-Meier Estimate
• Leukemia, Myeloid, Acute (genetics, mortality)
• Male
• MicroRNAs (genetics)
• Middle Aged
• Neoplasm Proteins (genetics)
• Prognosis
• Proportional Hazards Models
• Risk Factors
• Transcriptome
• Young Adult