Abstract |
While all herpesviruses can switch between lytic and latent life cycle, which are both driven by specific transcription programs, a unique feature of latent EBV infection is the expression of several distinct and well-defined viral latent transcription programs called latency I, II, and III. Growth transformation of B-cells by EBV in vitro is based on the concerted action of Epstein-Barr virus nuclear antigens (EBNAs) and latent membrane proteins(LMPs). EBV growth-transformed B-cells express a viral transcriptional program, termed latency III, which is characterized by the coexpression of EBNA2 and EBNA-LP with EBNA1, EBNA3A, -3B, and -3C as well as LMP1, LMP2A, and LMP2B. The focus of this review will be to discuss the current understanding of how two of these proteins, EBNA2 and EBNA-LP, contribute to EBV-mediated B-cell growth transformation.
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Authors | Bettina Kempkes, Paul D Ling |
Journal | Current topics in microbiology and immunology
(Curr Top Microbiol Immunol)
Vol. 391
Pg. 35-59
( 2015)
ISSN: 0070-217X [Print] Germany |
PMID | 26428371
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- EBNA-2 protein, Human herpesvirus 4
- EBNA-LP protein, Human herpesvirus 4
- Epstein-Barr Virus Nuclear Antigens
- Viral Proteins
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Topics |
- Animals
- B-Lymphocytes
(virology)
- Cell Transformation, Viral
- Epstein-Barr Virus Infections
(virology)
- Epstein-Barr Virus Nuclear Antigens
(genetics, metabolism)
- Gene Expression Regulation, Viral
- Herpesvirus 4, Human
(genetics, metabolism)
- Humans
- Viral Proteins
(genetics, metabolism)
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