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EBNA2 and Its Coactivator EBNA-LP.

Abstract
While all herpesviruses can switch between lytic and latent life cycle, which are both driven by specific transcription programs, a unique feature of latent EBV infection is the expression of several distinct and well-defined viral latent transcription programs called latency I, II, and III. Growth transformation of B-cells by EBV in vitro is based on the concerted action of Epstein-Barr virus nuclear antigens (EBNAs) and latent membrane proteins(LMPs). EBV growth-transformed B-cells express a viral transcriptional program, termed latency III, which is characterized by the coexpression of EBNA2 and EBNA-LP with EBNA1, EBNA3A, -3B, and -3C as well as LMP1, LMP2A, and LMP2B. The focus of this review will be to discuss the current understanding of how two of these proteins, EBNA2 and EBNA-LP, contribute to EBV-mediated B-cell growth transformation.
AuthorsBettina Kempkes, Paul D Ling
JournalCurrent topics in microbiology and immunology (Curr Top Microbiol Immunol) Vol. 391 Pg. 35-59 ( 2015) ISSN: 0070-217X [Print] Germany
PMID26428371 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • EBNA-2 protein, Human herpesvirus 4
  • EBNA-LP protein, Human herpesvirus 4
  • Epstein-Barr Virus Nuclear Antigens
  • Viral Proteins
Topics
  • Animals
  • B-Lymphocytes (virology)
  • Cell Transformation, Viral
  • Epstein-Barr Virus Infections (virology)
  • Epstein-Barr Virus Nuclear Antigens (genetics, metabolism)
  • Gene Expression Regulation, Viral
  • Herpesvirus 4, Human (genetics, metabolism)
  • Humans
  • Viral Proteins (genetics, metabolism)

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