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Lower Serum 25-Hydroxyvitamin D Level is Associated With 3 Types of Autoimmune Thyroid Diseases.

Abstract
Autoimmune thyroid diseases (AITD) are common autoimmune disorders. A few studies have analyzed the association between serum vitamin D levels and AITD, and available data remain inconclusive. The aim of this study was to evaluate the association between serum vitamin D levels and 3 types of AITD, that is Graves' disease (GD), Hashimoto's thyroiditis (HT), and postpartum thyroiditis (PPT). Two independent case-control studies were designed. The first is a cross-sectional case-control study in which we examined the levels of 25(OH)D in patients with newly diagnosed GD or HT and in controls; the second is a nested case-control study in which we compared 25(OH)D levels in 610 women who developed PPT during the follow-up after delivery and those who did not. Compared with the controls, GD patients and HT patients had significantly lower 25(OH)D levels. PPT cases also had a lower serum 25(OH)D concentration than controls. Serum 25(OH)D levels were associated with neither antithyroid peroxidase antibody nor antithyroglobulin antibody in GD and HT. There was no significant relationship between thyroid-stimulating hormone and 25(OH)D levels. Every 5 nmol/L increase in serum 25(OH)D concentrations was associated with a 1.55-, 1.62-, and 1.51-fold reduction in GD, HT, and PPT risk, respectively. We observed a lower serum vitamin D levels in AITD patients compared with controls. The lower the vitamin D level is, not vitamin D deficiency per se, the higher the risk for developing AITD will be. However, vitamin D does not have strong association with the titers of thyroid antibodies or the levels of thyroid hormones.
AuthorsJie Ma, Di Wu, Chenyang Li, Chenling Fan, Nannan Chao, Jing Liu, Yushu Li, Renee Wang, Wei Miao, Haixia Guan, Zhongyan Shan, Weiping Teng
JournalMedicine (Medicine (Baltimore)) Vol. 94 Issue 39 Pg. e1639 (Sep 2015) ISSN: 1536-5964 [Electronic] United States
PMID26426654 (Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
Chemical References
  • Autoantibodies
  • Receptors, Thyrotropin
  • Thyroid Hormones
  • anti-thyroglobulin
  • Vitamin D
  • 25-hydroxyvitamin D
Topics
  • Adolescent
  • Adult
  • Aged
  • Autoantibodies (blood)
  • Case-Control Studies
  • Cross-Sectional Studies
  • Female
  • Graves Disease (blood)
  • Hashimoto Disease (blood)
  • Humans
  • Male
  • Middle Aged
  • Postpartum Thyroiditis (blood)
  • Receptors, Thyrotropin (blood, immunology)
  • Thyroid Hormones (blood, immunology)
  • Vitamin D (analogs & derivatives, blood)
  • Young Adult

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