A "turn-on" fluorescent chemosensor for aluminum ion and cell imaging application.

Abstract

A simple and efficient fluorescent chemosensor for Al(3+) is reported in the paper. The chemosensor is obtained by dehydration reaction of 2-hydroxy-1-naphthaldehyde and 2-aminophenol. The chemosensor has high selectivity and sensitivity for Al(3+) and displays fluorescence "off-on" switch signal. The detection limit of the chemosensor for Al(3+) can reach 1.0×10(-7) M in DMSO/H2O (1:9, v/v) solution. The mass spectra and Job's plot analysis confirm the 1:1 stoichiometry between chemosensor and Al(3+). Potential utilization of the probe as an intracellular sensor of Al(3+) in human cancer (HiSa) cells is also examined by confocal fluorescence microscopy.

• Authors: Ailing Guo, Ruitao Zhu, Yuehong Ren, Jinlong Dong, Liheng Feng
• Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (Spectrochim Acta A Mol Biomol Spectrosc) Vol. 153 Pg. 530-4 (Jan 15 2016) ISSN: 1873-3557 [Electronic] England
• PMID: 26421494 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier B.V. All rights reserved.

Chemical References

• Fluorescent Dyes
• Ions
• Naphthalenes
• Solutions
• Aluminum

Topics

• Aluminum (chemistry)
• Cell Line, Tumor
• Fluorescent Dyes (chemistry)
• Humans
• Ions
• Molecular Imaging (methods)
• Naphthalenes (chemistry)
• Solutions
• Spectrometry, Fluorescence
• Spectrophotometry, Ultraviolet