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Intussusception in gestational choriocarcinoma (not histologically proven), resolving spontaneously with chemotherapy.

Abstract
We present a rare case of advanced gestational choriocarcinoma with small bowel metastatic involvement and intussusception, which presented acutely as a lower gastrointestinal bleed with symptomatic anaemia and haemoglobin 3.8 g/dL in a young woman. A diagnosis of gestational choriocarcinoma was made without biopsy, using a combination of clinical history, isolated elevated human chorionic gonadotropin markers of 77,000 IU/mL and radiological findings. Surgical intervention was too high risk due to the presence of active bleeding and increased vascularity surrounding the intussusception. Owing to the highly responsive nature of gestational choriocarcinoma to chemotherapy, frontline chemotherapy alone was used to reduce the size of the metastatic small bowel deposits, with subsequent resolution of the bleeding and intussusception. This is the first time chemotherapy alone has been used to successfully resolve small bowel intussusception secondary to metastatic choriocarcinoma that has been documented according to PubMed searches.
AuthorsAnisha Ramessur, Mark Openshaw, Naveed Sarwar
JournalBMJ case reports (BMJ Case Rep) Vol. 2015 (Sep 29 2015) ISSN: 1757-790X [Electronic] England
PMID26420692 (Publication Type: Case Reports, Journal Article)
Copyright2015 BMJ Publishing Group Ltd.
Chemical References
  • Etoposide
  • Cisplatin
Topics
  • Abdominal Pain (etiology)
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols
  • Blood Transfusion (methods)
  • Choriocarcinoma (drug therapy, pathology)
  • Cisplatin
  • Etoposide
  • Female
  • Fluid Therapy (methods)
  • Gastrointestinal Hemorrhage (etiology, pathology, therapy)
  • Humans
  • Intussusception (drug therapy, etiology, pathology)
  • Jejunal Neoplasms (drug therapy, pathology, secondary)
  • Melena (etiology, pathology)
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Uterine Neoplasms (complications, drug therapy, pathology)

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