Abstract | BACKGROUND: METHODS: One hundred fifty patients were studied at two academic centers using regadenoson (400-μg intravenous bolus) vasodilator stress RTMCE (7.5% Optison infusion [n = 50] or 1.5% Definity infusion [n = 100]). Both MP and WM with RTMCE were analyzed at rest and after regadenoson bolus. Comparisons of WM and MP sensitivity, specificity, and accuracy were made. Quantitative angiography was performed in all patients within 1 month of the regadenoson stress study (>50% and >70% diameter stenosis was considered significant). Reviewers were blinded to all clinical and quantitative angiographic data. RESULTS: Rate-pressure product after regadenoson was higher in Optison than Definity patients (P = .004). Using a 50% diameter stenosis on quantitative angiography as a reference standard, overall sensitivity, specificity, and accuracy for combined WM and MP analysis were not different for both agents ( Optison, 77%, 64%, and 73%; Definity, 80%, 74%, and 78%; P = NS). The sensitivity, specificity, and accuracy of WM analysis alone for Optison were 68%, 71%, and 69% compared with 60%, 72%, and 66% for Definity (P = NS). Adding MP analysis improved the sensitivity and accuracy of Definity for detecting both >50% and >70% stenoses (P < .001 vs WM), while MP analysis did not improve the sensitivity of Optison for detecting either >50 or >70% stenoses. CONCLUSIONS:
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Authors | Sahar S Abdelmoneim, Sharon L Mulvagh, Feng Xie, Edward O'Leary, Mary Adolphson, Mohamed A Omer, Lara F Nhola, Runqing Huang, Sara J Warta, Brenda Kirby, Thomas R Porter |
Journal | Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
(J Am Soc Echocardiogr)
Vol. 28
Issue 12
Pg. 1393-400
(Dec 2015)
ISSN: 1097-6795 [Electronic] United States |
PMID | 26416199
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Adenosine A2 Receptor Agonists
- Contrast Media
- Purines
- Pyrazoles
- regadenoson
|
Topics |
- Adenosine A2 Receptor Agonists
(administration & dosage)
- Contrast Media
(administration & dosage)
- Coronary Angiography
- Coronary Artery Disease
(diagnostic imaging)
- Echocardiography, Stress
(methods)
- Feasibility Studies
- Female
- Humans
- Injections, Intravenous
- Male
- Middle Aged
- Myocardial Perfusion Imaging
(methods)
- Purines
(administration & dosage)
- Pyrazoles
(administration & dosage)
- Reproducibility of Results
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