Encephalopathy with status epilepticus during sleep (ESES) induced by oxcarbazepine in idiopathic focal epilepsy in childhood.

Abstract

Encephalopathy with status epilepticus during sleep (ESES) is an age-related disorder characterized by neuropsychological regression, epilepsy and a typical EEG pattern of continuous epileptiform activity (> 85%) during NREM sleep. Cases of worsening or induction of ESES with phenytoin, carbamazepine and phenobarbital have been reported. We describe a child with benign epilepsy with centrotemporal spikes (BECTS) in whom treatment with oxcarbazepine (OXC) induced ESES. The patient was studied through repeated clinical-neuropsychological evaluations and 24-hour EEG recordings. He was treated with OXC two months after epilepsy onset. One month after starting OXC, he developed an abrupt and severe cognitive deterioration. A 24-hour EEG and neuropsychological tests showed an electroclinical picture compatible with ESES. Withdrawal of OXC and introduction of other drugs were followed by a prompt improvement. Five months after ESES onset, a 24-hour EEG was normal. Our report indicates that OXC can induce ESES in BECTS.

• Authors: Elena Pavlidis, Guido Rubboli, Marina Nikanorova, Margarethe Sophie Kölmel, Elena Gardella
• Journal: Functional neurology (Funct Neurol) 2015 Apr-Jun Vol. 30 Issue 2 Pg. 139-41 ISSN: 1971-3274 [Electronic] Italy
• PMID: 26415787 (Publication Type: Case Reports, Journal Article)

Chemical References

• Carbamazepine
• Oxcarbazepine

Topics

• Brain Diseases (chemically induced, complications)
• Carbamazepine (adverse effects, analogs & derivatives)
• Cerebral Cortex (physiopathology)
• Child
• Electroencephalography
• Epilepsies, Partial (complications)
• Humans
• Male
• Neuropsychological Tests
• Oxcarbazepine
• Sleep (physiology)
• Status Epilepticus (chemically induced, complications)