[Using "Collegel" complex in combined therapy of rectum cancer].

Abstract

The method of drug delivery to the site of lesion is an important component of drug effectiveness. To maximize the effectiveness of drugs LLC "Koletex" has developed and brought into practice the drug, "Collegel" for directed drug delivery. Hydrogel based composition "Collegel" is biopolymer consists of sodium alginate. In the gel-forming polymer one or more substance introduced on a specific technology. Studies have been conducted to examine the possibility of using hydrogel "Collegel" with 5-fluorouracil as radiomodifying agent in the treatment of rectal cancer. In the group of patients who received intrarectal introduction 5-fluorouracil, metastases were observed significantly less frequently (2.8%) than in the group of patients who received surgical treatment (15.2%) and preoperative radiotherapy in monoregimen (12.6%), as well as reduced doses capecitabine concomitantly with preoperative radiotherapy (11.4%), which gives the basis for the use of intrarectal way of introduction of therapeutic doses of 5-fluorouracil during preoperative chemoradiation therapy. The newly created method of complex treatment of patients with rectal cancer to ensure adequate local control of the disease. There is no local recurrence diagnosed over the 2-year follow-up period. We have considerable experience in the application of gel "Collegel" containing antioxidant and immunomodulator "Derinat" (deoxyribonuclease sodium) for the prevention and treatment of radiation damage to normal tissues during radiotherapy of malignant tumors. Patients can be treated without interruption and significantly reduces the incidence of adverse radiation damage.

• Authors: N D Oltarzhevskaia, M A Korovina, Iu A Barsukov, D V Kuz'michev, O A Malikhova
• Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology (Eksp Klin Gastroenterol) Issue 4 Pg. 77-82 ( 2015) ISSN: 1682-8658 [Print] Russia (Federation)
• PMID: 26415270 (Publication Type: Journal Article)

Chemical References

• Alginates
• Derinat
• Drug Carriers
• Hexuronic Acids
• Radiation-Protective Agents
• Hydrogel, Polyethylene Glycol Dimethacrylate
• Glucuronic Acid
• DNA
• Fluorouracil

Topics

• Administration, Rectal
• Alginates (chemistry)
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Combined Modality Therapy
• DNA (administration & dosage, therapeutic use)
• Disease-Free Survival
• Drug Carriers (chemistry)
• Female
• Fluorouracil (administration & dosage, therapeutic use)
• Glucuronic Acid (chemistry)
• Hexuronic Acids (chemistry)
• Humans
• Hydrogel, Polyethylene Glycol Dimethacrylate
• Male
• Middle Aged
• Radiation-Protective Agents (administration & dosage, therapeutic use)
• Radiotherapy, Adjuvant (adverse effects)
• Rectal Neoplasms (drug therapy, pathology, surgery, therapy)