Tissue Factor Expressed by Neutrophils: Another Piece in the Vascular Inflammation Puzzle.

Abstract

The transition from the classic role of neutrophils as the first line of defense of the immune system to that of physiological regulators of intravascular thrombosis took nearly three decades to emerge. This transition needed time to unravel the complex links between the mechanisms that regulate hemostasis and inflammation and the innate immune response, multicellular and multifactorial processes that interact with each other. The present review is focused on the expression of tissue factor by neutrophils, a critical event in their inflammatory and thrombotic function.

• Authors: Norma Maugeri, Angelo A Manfredi
• Journal: Seminars in thrombosis and hemostasis (Semin Thromb Hemost) Vol. 41 Issue 7 Pg. 728-36 (Oct 2015) ISSN: 1098-9064 [Electronic] United States
• PMID: 26408925 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Chemical References

• Thromboplastin

Topics

• Animals
• Gene Expression Regulation
• Humans
• Inflammation (metabolism, pathology)
• Neutrophils (metabolism, pathology)
• Thromboplastin (biosynthesis)
• Thrombosis (metabolism, pathology)