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Dual loading miR-218 mimics and Temozolomide using AuCOOH@FA-CS drug delivery system: promising targeted anti-tumor drug delivery system with sequential release functions.

AbstractBACKGROUND:
Dual loading drug delivery system with tumor targeting efficacy and sequential release function provides a promising platform for anticancer drug delivery. Herein, we established a novel AuCOOH@FACS nanogel system for co-delivery miR-218 mimics (as bio-drug) and Temozolomide(as chemo-drug).
METHODS:
DLS and TEM were employed to determine the characteristics of particles and nanogels. The cell viability was calculated for study synergistic effect of both drugs coadministration and in nanogel forms. The amounts of Au uptake were measured by ICP-MS in cell and tumors to quantify the targeting drug delivery efficacy. Tumor weight and mice weight were investigated to study the targeting antitumor efficacy of nanogel system.
RESULTS:
The results revealed that using AuCOOH@FACS nanogel as delivery vehicles, drugs could be targeting delivery to tumor site, the intracellular uptake is enhanced to a greater extent, and significant antitumor efficacy is fold increase compared with free drug administration group, without noticeable system cytotoxicity.
CONCLUSIONS:
This system offers an efficient approach to cancer therapy and holds significant potential to improve the treatment of cancer in the future.
AuthorsLi Fan, Qian Yang, Jiali Tan, Youbei Qiao, Qiaofeng Wang, Jingya He, Hong Wu, Yongsheng Zhang
JournalJournal of experimental & clinical cancer research : CR (J Exp Clin Cancer Res) Vol. 34 Pg. 106 (Sep 25 2015) ISSN: 1756-9966 [Electronic] England
PMID26407971 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Retracted Publication)
Chemical References
  • 11-mercaptoundecanoic acid
  • Antineoplastic Agents, Alkylating
  • Delayed-Action Preparations
  • Fatty Acids
  • Gold Compounds
  • MIRN218 microRNA, human
  • MicroRNAs
  • Nanogels
  • Sulfhydryl Compounds
  • polyethylene glycol polyethyleneimine nanogel
  • Polyethylene Glycols
  • Dacarbazine
  • Polyethyleneimine
  • Chitosan
  • Temozolomide
Topics
  • Animals
  • Antineoplastic Agents, Alkylating (pharmacology)
  • Antineoplastic Combined Chemotherapy Protocols (pharmacology)
  • Cell Line, Tumor
  • Chitosan (chemistry)
  • Dacarbazine (analogs & derivatives, pharmacology)
  • Delayed-Action Preparations
  • Drug Delivery Systems (methods)
  • Fatty Acids (chemistry)
  • Female
  • Glioblastoma (drug therapy)
  • Gold Compounds (chemistry, pharmacology)
  • Humans
  • Metal Nanoparticles (chemistry)
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • MicroRNAs (pharmacology)
  • Nanogels
  • Polyethylene Glycols (pharmacology)
  • Polyethyleneimine (pharmacology)
  • Sulfhydryl Compounds (chemistry)
  • Temozolomide
  • Xenograft Model Antitumor Assays

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