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Clinicopathological significance and prognostic value of Wilms' tumor gene expression in colorectal cancer.

AbstractBACKGROUND:
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers, and novel effective treatments and diagnostic tools are urgently required.
OBJECTIVE:
The selection of appropriate targeting tumor-associated antigens (TAAs) is critical for immunotherapy. Therefore, we analyzed TAA expression levels and investigated their relationship with clinical factors in adjacent normal mucosa (ANM) and CRC tissue.
METHODS:
We obtained specimens of CRC primary tumors and matched ANM from 137 patients with CRC who underwent surgical resection. The mRNA levels of seven TAAs, Wilms' tumor gene (WT1), kinetochore associated-2 (KNTC2), cell division cycle associated-1 (CDCA1), M phase phosphoprotein-1 (MPHOSPH1), DEP domain-containing 1 (DEPDC1), 34-kDa translocase of the outer mitochondrial membrane (TOMM34) and ring finger protein-43 (RNF43), were analyzed using quantitative real-time reverse transcription-polymerase chain reaction, and their relationships with clinicopathological factors and the cell cycle were analyzed.
RESULTS:
The expression levels of all seven TAAs were significantly higher in CRC tissues than in ANM. Expression levels of WT1 in CRC tissues did not correlate with the cell cycle. Furthermore, WT1 expression in CRC tissues was significantly related to tumor progression, lymph node metastasis, distant metastasis and clinical stage.
CONCLUSIONS:
WT1 is a potential marker for prognosis and tumor progression in CRC.
AuthorsYukinaga Miyata, Kenichi Kumagai, Tomoko Nagaoka, Kazutaka Kitaura, Goro Kaneda, Hideki Kanazawa, Satsuki Suzuki, Yoshiki Hamada, Ryuji Suzuki
JournalCancer biomarkers : section A of Disease markers (Cancer Biomark) Vol. 15 Issue 6 Pg. 789-97 ( 2015) ISSN: 1875-8592 [Electronic] Netherlands
PMID26406403 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers, Tumor
  • Cell Cycle Proteins
  • RNA, Messenger
  • WT1 Proteins
  • WT1 protein, human
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor (genetics)
  • Case-Control Studies
  • Cell Cycle Proteins (genetics)
  • Colorectal Neoplasms (genetics, pathology, surgery)
  • Female
  • Follow-Up Studies
  • Humans
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Prognosis
  • RNA, Messenger (genetics)
  • Real-Time Polymerase Chain Reaction
  • Reverse Transcriptase Polymerase Chain Reaction
  • WT1 Proteins (genetics)

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