Studies on batch formulation of a kit for the preparation of the 99mTc-Ubiquicidin (29-41): An infection imaging agent.

Abstract

The aim of this study was to formulate an indigenous cold kit of Ubiquicidin, UBI (29-41), for easy preparation of (99m)Tc-UBI (29-41) to be used as an infection imaging agent. A two component kit with the peptide and SnCl2 as vial 1 and optimum amount of NaOH as vial 2 was successfully formulated as seen from the consistent radiochemical and pharmaceutical purity of the product over six consecutive batches of kits. The utility of the kit could be demonstrated through in-vitro and in vivo specificity of (99m)Tc-UBI (29-41).

• Authors: Chanda Arjun, Archana Mukherjee, Jyotsna Bhatt, Pradip Chaudhari, Krishna Mohan Repaka, Meera Venkatesh, Grace Samuel
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 107 Pg. 8-12 (Jan 2016) ISSN: 1872-9800 [Electronic] England
• PMID: 26405838 (Publication Type: Evaluation Study, Journal Article)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Organotechnetium Compounds
• Peptide Fragments
• Radiopharmaceuticals
• technetium 99m ubiquicidin(29-41)

Topics

• Animals
• Chemistry, Pharmaceutical
• Drug Stability
• Freeze Drying
• Humans
• Infections (diagnostic imaging)
• Mice
• Organotechnetium Compounds (isolation & purification, pharmacokinetics)
• Peptide Fragments (isolation & purification, pharmacokinetics)
• Radionuclide Imaging
• Radiopharmaceuticals (isolation & purification, pharmacokinetics)
• Tissue Distribution