The Role of Visinin-Like Protein-1 in the Pathophysiology of Alzheimer's Disease.

Abstract

Calcium ions are crucial in the process of information transmission and integration in the central nervous system (CNS). These ions participate not only in intracellular mechanisms but also in intercellular processes. The changes in the concentration of Ca2 + ions modulate synaptic transmission, whereas neuronal activity induces calcium ion waves. Disturbed calcium homeostasis is thought to be one of the main features in the pathophysiology of Alzheimer's disease (AD), and AD pathogenesis is closely connected to Ca2 + signaling pathways. The effects of changes in neuronal Ca2 + are mediated by neuronal calcium sensor (NCS) proteins. It has been revealed that NCS proteins, with special attention to visinin-like protein 1 (VILIP-1), might have a connection to the etiology of AD. In the CNS, VILIP-1 influences the intracellular neuronal signaling pathways involved in synaptic plasticity, such as cyclic nucleotide cascades and nicotinergic signaling. This particular protein is implicated in calcium-mediated neuronal injury as well. VILIP-1 also participates in the pathological mechanisms of altered Ca2 + homeostasis, leading to neuronal loss. These findings confirm the utility of VILIP-1 as a useful biomarker of neuronal injury. Moreover, VILIP-1 plays a vital role in linking calcium-mediated neurotoxicity and AD-type pathological changes. The disruption of Ca2 + homeostasis caused by AD-type neurodegeneration may result in the damage of VILIP-1-containing neurons in the brain, leading to increased cerebrospinal fluid levels of VILIP-1. Thus, the aim of this overview is to describe the relationships of the NCS protein VILIP-1 with the pathogenetic factors of AD and neurodegenerative processes, as well as its potential clinical usefulness as a biomarker of AD. Moreover, we describe the current and probable therapeutic strategies for AD, targeting calcium-signaling pathways and VILIP-1.

• Authors: Magdalena Groblewska, Paweł Muszyński, Aleksandra Wojtulewska-Supron, Agnieszka Kulczyńska-Przybik, Barbara Mroczko
• Journal: Journal of Alzheimer's disease : JAD (J Alzheimers Dis) Vol. 47 Issue 1 Pg. 17-32 ( 2015) ISSN: 1875-8908 [Electronic] Netherlands
• PMID: 26402751 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Neurocalcin
• RNA, Messenger
• VSNL1 protein, human

Topics

• Alzheimer Disease (genetics, pathology, physiopathology)
• Animals
• Calcium Signaling (physiology)
• Central Nervous System (metabolism)
• Humans
• Neurocalcin (genetics, metabolism)
• Neurodegenerative Diseases (metabolism)
• RNA, Messenger (metabolism)