Abstract | BACKGROUND: METHODS: RESULTS: Baseline protein breakdown and protein synthesis were higher in cachectic patients compared with the controls (breakdown: 67.1 (48.1-79.6) vs. 45.8 (42.6-46.3) µmol/kg lean body mass/h, P = 0.049; and synthesis: 63.0 (44.3-75.6) vs. 41.8 (37.6-42.5) µmol/kg lean body mass/h, P = 0.021). During feeding, protein breakdown decreased significantly to 45.5 (26.9-51.1) µmol/kg lean body mass/h (P = 0.012) in the cachexia group and to 33.7 (17.4-37.1) µmol/kg lean body mass/h (P = 0.018) in the control group. Protein synthesis was not affected by feeding in cachectic patients: 58.4 (46.5-76.1) µmol/kg lean body mass/h, but was stimulated in controls: 47.9 (41.8-56.7) µmol/kg lean body mass/h (P = 0.018). Both groups showed a comparable positive net protein balance during feeding: cachexia: 19.7 (13.1-23.7) and control: 16.3 (13.6-25.4) µmol/kg lean body mass/h (P = 0.908). CONCLUSION: Cachectic pancreatic cancer patients have a higher basal protein turnover. Both cachectic patients and controls show a comparable protein anabolism during feeding, albeit through a different pattern of protein kinetics. In cachectic patients, this is primarily related to reduced protein breakdown, whereas in controls, both protein breakdown and protein synthesis alterations are involved.
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Authors | David Pj van Dijk, Marcel Cg van de Poll, Alastair Gw Moses, Thomas Preston, Steven Wm Olde Damink, Sander S Rensen, Nicolaas Ep Deutz, Peter B Soeters, James A Ross, Kenneth Ch Fearon, Cornelis Hc Dejong |
Journal | Journal of cachexia, sarcopenia and muscle
(J Cachexia Sarcopenia Muscle)
Vol. 6
Issue 3
Pg. 212-21
(Sep 2015)
ISSN: 2190-5991 [Print] Germany |
PMID | 26401467
(Publication Type: Journal Article)
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