Elevated serum IgG4 levels in two cases of paragonimiasis.

Abstract

Paragonimiasis is a parasitic pleuropulmonary infection caused by eating raw crustaceans and wild boar meat and this infection is endemic in Asia. We herein report two cases of pulmonary P aragonimus westermani infection associated with elevated levels of serum immunoglobulin (Ig) G4 and dense infiltration of IgG4-positive plasma cells in the lung lesions. Treatment with praziquantel resolved the pulmonary lesions and decreased the serum levels of IgG4. IgG4-related disease is a systemic disease occasionally involving the lungs and leads to increased serum levels of IgG4. Our findings suggest that P. westermani infection requires a differential diagnosis from IgG4-related diseases and the serum IgG4 level may be a potentially useful marker of P. westermani infection.

• Authors: Sho Saeki, Yuko Horio, Susumu Hirosako, Hidenori Ichiyasu, Kazuhiko Fujii, Hirotsugu Kohrogi
• Journal: Respirology case reports (Respirol Case Rep) Vol. 3 Issue 3 Pg. 92-4 (Sep 2015) ISSN: 2051-3380 [Print] United States
• PMID: 26392854 (Publication Type: Case Reports)