Liver transplant for biliary atresia is associated with a worse outcome - Myth or fact?

Abstract

BACKGROUND:

Liver transplant for biliary atresia (BA) has been reported to be associated with worse outcome, but this remains controversial. The objective of this study is to compare the outcomes of BA and non-BA recipients.

METHODS:

Recipients with age <18years were reviewed except cases of retransplantation. Intratransplant and posttransplant complications as well as survivals were evaluated.

RESULTS:

119 patients, with median follow-up period 8.5years, were studied (DDLT=33; LDLT=86/M:F=56:63), and 68% (n=81) were BA patients. While demographic data were comparable between two groups of recipients, BA patients had a worse pretransplant PELD/MELD score (15.2 vs 4.0, p=0.021). Transplantation takes a longer time in the BA group (580min vs 400min, p=0.065) with more blood loss (720ml vs 500ml, p=0.072). The incidence of transplant-related complications was 30.3% (36/119) (Table 1). There was no significant difference between incidences of vascular complication, but biliary complication was more common in the BA group. Overall, the survivals between the two groups were comparable.

CONCLUSIONS:

Liver transplant is an effective surgical treatment for BA patients. When compared to other indications, results are not inferior. Previous Kasai operation is not necessarily associated with adverse outcomes.

• Authors: Patrick Ho Yu Chung, Kenneth Kak Yuen Wong, See Ching Chan, Paul Kwong Hang Tam
• Journal: Journal of pediatric surgery (J Pediatr Surg) Vol. 50 Issue 12 Pg. 2134-6 (Dec 2015) ISSN: 1531-5037 [Electronic] United States
• PMID: 26392059 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Topics

• Adolescent
• Biliary Atresia (surgery)
• Child, Preschool
• Female
• Humans
• Infant
• Liver Transplantation
• Male
• Survival Analysis
• Time Factors
• Treatment Outcome