Abstract | BACKGROUND: There are many chemical sensitizers which cause allergy in the surrounding environment. However, the identification of substances causing allergy is difficult. We developed a new method to detect IgG which reacts against many kinds of chemical- human serum albumin (HSA) adducts at the same time. In this study, the diagnostic significance of the IgG was studied among workers of a company where a mass outbreak of chemical dermatitis had occurred after changing a plastic resin to a new one. METHODS: Eleven workers who handled the new plastic resin and suffered from dermatitis (case) and 9 workers who also handled the same resin in the same company but were free from dermatitis (control) were the subjects. Immunological dot blotting was carried out to detect serum IgG using originally prepared diagnostic antigens, comprising a mixture of HSA and the plastic resin or its components under various conditions. RESULTS: DISCUSSION: This suggests that IgG against chemical-HSA adduct reflects not only exposure but also causative chemicals of dermatitis. Our method to use a material itself as a hapten is practical and useful in the occupational field. CONCLUSION: It is suggested that IgG against chemicals is a useful marker of chemicals inducing dermatitis.
|
Authors | Toshihiro Kawamoto, Mayumi Tsuji, Toyohi Isse |
Journal | BMC public health
(BMC Public Health)
Vol. 15
Pg. 930
(Sep 21 2015)
ISSN: 1471-2458 [Electronic] England |
PMID | 26390923
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Benzhydryl Compounds
- Epoxy Compounds
- Epoxy Resins
- Immunoglobulin G
- Plastics
- Xylenes
- 1,3-xylenediamine
- 2,2-bis(4-glycidyloxyphenyl)propane
|
Topics |
- Adult
- Benzhydryl Compounds
(adverse effects)
- Dermatitis, Allergic Contact
(diagnosis, immunology)
- Dermatitis, Occupational
(diagnosis, immunology)
- Epoxy Compounds
(adverse effects)
- Epoxy Resins
(adverse effects)
- Humans
- Immunoglobulin G
(metabolism)
- Male
- Middle Aged
- Patch Tests
(methods)
- Plastics
(adverse effects)
- Xylenes
(adverse effects)
|