Experimental Study of the Mechanisms of Intracellular Defense in Cardiomyocytes Associated with Stages of Anthracosilicosis Development.

Abstract

Mechanisms of intracellular defense of rat cardiomyocytes were studied in dynamics of anthracosilicosis development induced by long-term inhalation of coal and rock dust. It was shown that synthesis of transcription factor HIF-1α and protective proteins increased in the heart at the early stages of coal and rock dust inhalation (1-3 weeks), and these changes limited the development of free radical oxidation and activated metabolism of glucose and fatty acids. Exposure to coal and rock dust for 6-12 weeks activated free radical oxidation and decreased basal metabolism in cardiomyocytes.

• Authors: V V Zakharenkov, N N Mikhailova, N N Zhdanova, L G Gorokhova, A G Zhukova
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 159 Issue 4 Pg. 431-4 (Aug 2015) ISSN: 1573-8221 [Electronic] United States
• PMID: 26388578 (Publication Type: Journal Article)

Chemical References

• HSP72 Heat-Shock Proteins
• Hif1a protein, rat
• Hypoxia-Inducible Factor 1, alpha Subunit
• Heme Oxygenase (Decyclizing)
• heme oxygenase-2

Topics

• Animals
• Anthracosilicosis (pathology)
• HSP72 Heat-Shock Proteins (metabolism)
• Heme Oxygenase (Decyclizing) (metabolism)
• Hypoxia-Inducible Factor 1, alpha Subunit (metabolism)
• Male
• Myocardium (metabolism)
• Myocytes, Cardiac (metabolism)
• Oxidation-Reduction
• Protective Factors
• Rats, Wistar