Abstract | AIM: To evaluate the safety and efficacy of intralesional injection of human embryonic stem cell (hESC)-derived mesenchymal stem/stromal cells (MSCs) in canine anal furunculosis dogs. MATERIALS & METHODS: Dogs naturally develop an immune-mediated disease called canine anal furunculosis, which shares many features with human fistulizing Crohn's disease. RESULTS: The hESC-MSCs were well tolerated and 1 month postinjection, accompanied by reduced serum levels of IL-2 and IL-6, two inflammatory cytokines associated with Crohn's disease. All six dogs were found to be completely free of fistulas at 3 months postinjection. However, at 6 months, two dogs had some fistula relapse. CONCLUSION: Results of this study provide the first evidence of the safety and therapeutic potential of hESC-MSCs in a large animal model.
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Authors | Lluís Ferrer, Erin A Kimbrel, Andrea Lam, Elizabeth B Falk, Christine Zewe, Tarja Juopperi, Robert Lanza, Andrew Hoffman |
Journal | Regenerative medicine
(Regen Med)
Vol. 11
Issue 1
Pg. 33-43
(Jan 2016)
ISSN: 1746-076X [Electronic] England |
PMID | 26387424
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Crohn Disease
(drug therapy, therapy)
- Cyclosporine
(pharmacology, therapeutic use)
- Cytokines
(blood)
- Disease Models, Animal
- Dogs
- Dose-Response Relationship, Drug
- Follow-Up Studies
- Heterografts
- Human Embryonic Stem Cells
(cytology)
- Humans
- Immunomodulation
- Mesenchymal Stem Cell Transplantation
- Mesenchymal Stem Cells
(cytology)
- Rectal Fistula
(therapy)
- Stromal Cells
(cytology)
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