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Advanced glycation end products: A link between metabolic and endothelial dysfunction in polycystic ovary syndrome?

Abstract
Polycystic ovary syndrome (PCOS), a heterogeneous syndrome of reproductive and metabolic alterations, is associated with increased long-term risk of cardiovascular complications. This phenomenon has been linked to an increase in oxidative stress and inflammatory markers. Advanced glycation end products (AGEs) are pro-inflammatory molecules that trigger a state of intracellular oxidative stress and inflammation after binding to their cell membrane receptors RAGE. The activation of the AGE-RAGE axis has been well known to play a role in atherosclerosis in both men and women. Women with PCOS have systemic chronic inflammatory condition even at the ovarian level as represented by elevated levels of serum/ovarian AGEs and increased expression of the pro-inflammatory RAGE in ovarian tissue. Data also showed the presence of sRAGE in the follicular fluid and its potential protective role against the harmful effect of AGEs on ovarian function. Thus, whether AGE-RAGE axis constitutes a link between metabolic and endothelial dysfunction in women with PCOS is addressed in this review. Additionally, we discuss the role of hormonal changes observed in PCOS and how they are linked with the AGE-RAGE axis in order to better understand the nature of this complex syndrome whose consequences extend well beyond reproduction.
AuthorsMagdalena Pertynska-Marczewska, Evanthia Diamanti-Kandarakis, John Zhang, Zaher Merhi
JournalMetabolism: clinical and experimental (Metabolism) Vol. 64 Issue 11 Pg. 1564-73 (Nov 2015) ISSN: 1532-8600 [Electronic] United States
PMID26386695 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2015 Elsevier Inc. All rights reserved.
Chemical References
  • Glycation End Products, Advanced
  • Receptor for Advanced Glycation End Products
Topics
  • Adiposity
  • Endothelium, Vascular (physiopathology)
  • Female
  • Glycation End Products, Advanced
  • Humans
  • Insulin Resistance
  • Polycystic Ovary Syndrome (metabolism, physiopathology)
  • Receptor for Advanced Glycation End Products (metabolism)

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