Abstract | OBJECTIVE: METHODS: RESULTS: Maximum standardized uptake values and the expression of hypoxia-inducible factor 1α and glucose transporter 1 were significantly higher in squamous cell carcinoma than in adenocarcinoma (P < 0.001, P = 0.034 and P < 0.001, respectively). In adenocarcinoma, but not squamous cell carcinoma, maximum standardized uptake values, hypoxia-inducible factor 1α and glucose transporter 1 correlated with various clinicopathological factors relating to malignancy, and maximum standardized uptake values and glucose transporter 1 were associated with disease-free survival (P < 0.001 and P = 0.029) and overall survival (P < 0.001 and P = 0.033, respectively). Patients with high expression of hypoxia-inducible factor 1α tended to exhibit shorter disease-free survival and overall survival than those with low expression, but the differences were not significant (P = 0.32 and P = 0.15, respectively). And then in adenocarcinoma, hypoxia-inducible factor 1α and glucose transporter 1, glucose transporter 1 and maximum standardized uptake values, and hypoxia-inducible factor 1α and maximum standardized uptake values were significantly correlated (P < 0.001 for all), suggesting that hypoxia-inducible factor 1α-induced glucose transporter 1 might influence maximum standardized uptake values on [(18)F]-fluoro- 2-deoxyglucose positron emission tomography. CONCLUSIONS:
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Authors | Takaoki Furukawa, Yoshihiro Miyata, Kei Kushitani, Takahiro Mimae, Yasuhiro Tsutani, Yukio Takeshima, Morihito Okada |
Journal | Japanese journal of clinical oncology
(Jpn J Clin Oncol)
Vol. 45
Issue 12
Pg. 1154-61
(Dec 2015)
ISSN: 1465-3621 [Electronic] England |
PMID | 26386467
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: [email protected]. |
Chemical References |
- Glucose Transporter Type 1
- HIF1A protein, human
- Hypoxia-Inducible Factor 1, alpha Subunit
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
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Topics |
- Adenocarcinoma
(diagnostic imaging, metabolism, surgery)
- Adenocarcinoma of Lung
- Aged
- Carcinoma, Non-Small-Cell Lung
(diagnostic imaging, metabolism, surgery)
- Disease-Free Survival
- Female
- Fluorodeoxyglucose F18
(metabolism)
- Gene Expression Regulation, Neoplastic
- Glucose Transporter Type 1
(metabolism)
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit
(metabolism)
- Lung Neoplasms
(diagnostic imaging, metabolism, surgery)
- Male
- Middle Aged
- Pneumonectomy
- Positron-Emission Tomography
- Radiopharmaceuticals
(metabolism)
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