Dengue viruses cluster antigenically but not as discrete serotypes.

Abstract

The four genetically divergent dengue virus (DENV) types are traditionally classified as serotypes. Antigenic and genetic differences among the DENV types influence disease outcome, vaccine-induced protection, epidemic magnitude, and viral evolution. We characterized antigenic diversity in the DENV types by antigenic maps constructed from neutralizing antibody titers obtained from African green monkeys and after human vaccination and natural infections. Genetically, geographically, and temporally, diverse DENV isolates clustered loosely by type, but we found that many are as similar antigenically to a virus of a different type as to some viruses of the same type. Primary infection antisera did not neutralize all viruses of the same DENV type any better than other types did up to 2 years after infection and did not show improved neutralization to homologous type isolates. That the canonical DENV types are not antigenically homogeneous has implications for vaccination and research on the dynamics of immunity, disease, and the evolution of DENV.

• Authors: Leah C Katzelnick, Judith M Fonville, Gregory D Gromowski, Jose Bustos Arriaga, Angela Green, Sarah L James, Louis Lau, Magelda Montoya, Chunling Wang, Laura A VanBlargan, Colin A Russell, Hlaing Myat Thu, Theodore C Pierson, Philippe Buchy, John G Aaskov, Jorge L Muñoz-Jordán, Nikos Vasilakis, Robert V Gibbons, Robert B Tesh, Albert D M E Osterhaus, Ron A M Fouchier, Anna Durbin, Cameron P Simmons, Edward C Holmes, Eva Harris, Stephen S Whitehead, Derek J Smith
• Journal: Science (New York, N.Y.) (Science) Vol. 349 Issue 6254 Pg. 1338-43 (Sep 18 2015) ISSN: 1095-9203 [Electronic] United States
• PMID: 26383952 (Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015, American Association for the Advancement of Science.

Chemical References

• Antibodies, Neutralizing
• Antibodies, Viral
• Antigens, Viral
• Dengue Vaccines
• E protein, Dengue virus type 3
• Immune Sera
• Viral Envelope Proteins
• glycoprotein E, dengue virus type 4
• E protein TH Sman, Dengue virus

Topics

• Animals
• Antibodies, Neutralizing (immunology)
• Antibodies, Viral (immunology)
• Antigens, Viral (immunology)
• Chlorocebus aethiops
• Dengue Vaccines (immunology)
• Dengue Virus (classification, genetics, immunology)
• Evolution, Molecular
• Humans
• Immune Sera (immunology)
• Phylogeny
• Serogroup
• Serotyping
• Vaccination
• Viral Envelope Proteins (genetics)