[Treatment of Sepsis-associated Encephalopathy by Xingnaojing Injection: a Clinical Observation].

Abstract

OBJECTIVE:

To observe the efficacy of Xingnaojing Injection (XI) in treatment of sepsis-associated encephalopathy (SAE).

METHODS:

Totally 65 SAE patients were retrospectively analyzed at EICU from September 2010 to September 2013. They were assigned to the control group (32 cases) and the treatment group (33 cases) according to whether they received XI. Patients in the control group received anti-infection and symptomatic support, while those in the treatment group were intravenously injected with XI at 20 mL per day for additional 7-10 days. The fever clearance time, Glasgow coma scale (GCS), C-reactive protein (CRP), neuron-specific enolase (NSE), and improvement of electroen-cephalogram (EEG) were observed in the two groups.

RESULTS:

Compared with the control group, the fever clearance time was shortened, CRP levels decreased, GCS score and efficacy of EEG was alleviated in the treatment group after treatment with statistical difference (P < 0.05). No adverse reaction occurred during medication.

CONCLUSION:

X1 was safe and effective in treatment of SAE.

• Authors: Su Lv, Jia Li, Bao-ping Cao, Ji-hong Zhu
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 35 Issue 7 Pg. 792-5 (Jul 2015) ISSN: 1003-5370 [Print] China
• PMID: 26380440 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Drugs, Chinese Herbal
• xingnaojing
• C-Reactive Protein
• Phosphopyruvate Hydratase

Topics

• C-Reactive Protein (metabolism)
• Drugs, Chinese Herbal (administration & dosage, therapeutic use)
• Humans
• Injections
• Phosphopyruvate Hydratase (metabolism)
• Sepsis-Associated Encephalopathy (drug therapy)
• Treatment Outcome